関連する実験動画

Updated: Feb 19, 2026

Continuous Fluorescence-Based Endonuclease-Coupled DNA Methylation Assay to Screen for DNA Methyltransferase Inhibitors
06:07

Continuous Fluorescence-Based Endonuclease-Coupled DNA Methylation Assay to Screen for DNA Methyltransferase Inhibitors

Published on: August 5, 2022

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協調DNAメチルトランスフェラーゼ3Aとメチルトランスフェラーゼ型7Aの活動により,ディスクイジン領域受容体1のシグナル伝達により,腫瘍の微環境が再プログラムされます

Zhengyang Bai1, Dan Yang1, Jiayi Li2

  • 1The First Clinical Medical School of Ningxia Medical University (General Hospital of Ningxia Medical University), Yinchuan 750004, China.

Cancer biology & medicine
|February 17, 2026
PubMed
まとめ

エピジェネティックレギュレータであるDNMT3AとMETTL7Aは,DDR1/STAT3/CXCL5軸を制御することで乳がんの再発を誘発し,免疫逃避と腫瘍の成長を促します. DDR1を静音化することで,これらの効果は逆転し,新たな治療目標を提供した.

キーワード:
DNMT3Aは,DNMT3Aとして使用されています.ディスコイドリン領域受容体1METTL7AはMETTL7Aとして使われています.腫瘍のマイクロ環境

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