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関連する概念動画

The JAK-STAT Signaling Pathway01:20

The JAK-STAT Signaling Pathway

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Several cytokine receptors have tightly bound Janus kinase or JAK proteins attached at their cytosolic tail. Small signaling molecules such as cytokines, growth hormones, or prolactins bind to the cytokine receptors and initiate their dimerization. The dimerization brings the cytosolic JAKs together that trans-phosphorylate and activates each other. The activated JAKs now phosphorylate cytosolic tails of the cytokine receptors, which serve as binding sites for adaptor proteins such as  SH2...
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The Early Endosome: Endocytosis of Transferrin01:28

The Early Endosome: Endocytosis of Transferrin

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Essential proteins such as insulin or low-density lipoprotein (LDL) and micronutrients such as iron enter a eukaryotic cell through receptor-mediated endocytosis. Subsequently, the early endosomes fuse with the vesicles containing such receptor-ligand complexes and play a vital role in sorting the incoming ligands and receptors. While the ligands are either degraded inside the vesicle or released into the cytosol, their receptors are returned to the plasma membrane for further rounds of...
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Lysosomal Hydrolases01:22

Lysosomal Hydrolases

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Lysosomes are the site for the degradation of macromolecules and biological polymers released during membrane trafficking events such as secretory, endocytic, autophagic, and phagocytic pathways. The membrane-enclosed area of the lysosome, called the lumen, contains hydrolytic enzymes active in an acidic environment. These acid hydrolases are functional at a pH between 4.5 and 5 and are involved in cellular processes such as cell signaling, energy metabolism, restoration of the plasma membrane,...
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PI3K/mTOR/AKT Signaling Pathway01:22

PI3K/mTOR/AKT Signaling Pathway

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The mammalian target of rapamycin  (mTOR) is a serine/threonine kinase that regulates growth, proliferation, and cell survival in response to hormones, growth factors, or nutrient availability. This kinase exists in two structurally and functionally distinct forms: mTOR complex 1  (mTORC1) and mTOR complex 2  (mTORC2). The first form (mTORC1) is composed of a rapamycin-sensitive Raptor and proline-rich Akt substrate, PRAS40. In contrast,  mTORC2 consists of a...
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Phosphoinositides and PIPs01:42

Phosphoinositides and PIPs

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Phosphoinositides are a group of phospholipids containing a glycerol backbone with two fatty acid chains and a phosphate attached to a myoinositol sugar ring. The inositol head group extends into the cytoplasm, where it is modified by adding phosphate groups to form phosphatidylinositol phosphates or PIPs.
Different phosphoinositides are synthesized and recruited on the cytosolic face of the plasma membrane. The localization of specific phosphoinositides concentrated in separate membrane...
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Abnormal Proliferation02:23

Abnormal Proliferation

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Under normal conditions, most adult cells remain in a non-proliferative state unless stimulated by internal or external factors to replace lost cells. Abnormal cell proliferation is a condition in which the cell's growth exceeds and is uncoordinated with normal cells. In such situations, cell division persists in the same excessive manner even after cessation of the stimuli, leading to persistent tumors. The tumor arises from the damaged cells that replicate to pass the damage to the...
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Updated: Feb 19, 2026

Evaluating Therapeutic Interventions in the SHIP-deficient Mouse Model of Crohn Disease-like Ileitis and Fibrosis
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Evaluating Therapeutic Interventions in the SHIP-deficient Mouse Model of Crohn Disease-like Ileitis and Fibrosis

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後期エンドソーム/ライソーム機能の低下は,慢性PI3k活動とSHP-1/SHIP-1欠陥を通してSLEを促進する.

SunAh Kang1, Andrew J Monteith1, Liubov Arbeeva2

  • 1Department of Microbiology and Immunology, University of North Carolina, Chapel Hill, United States of America.

JCI insight
|February 17, 2026
PubMed
まとめ

システミック・ルプス・エリテマトーサス (SLE) 患者では,末期のエンドソームとリゾソーム (LEL) の酸化が低下し,細胞廃棄物の蓄積と免疫複合体の蓄積につながる. この機能障害は,特定のSLE疾患のバイオマーカーとして機能する可能性があります.

キーワード:
自己免疫性疾患は自己免疫性疾患である.自己免疫とは,自己免疫である.免疫学 免疫学とは狼 (ルプス) とはライソソームはライソソームである.

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Author Spotlight: Exploring the Role of Inflammation in the Co-occurrence of Primary Sjogren's Syndrome and Lung Adenocarcinoma
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科学分野:

  • 免疫学 免疫学とは
  • 細胞生物学 細胞生物学
  • 病理生理学 病理生理学とは

背景:

  • 細胞の廃棄物の分解は,エンドソームとリソソーム (LEL) の遅い酸性化によって活性化される水解酵素に依存しています.
  • 機能不全のLEL酸性化は,様々な疾患に関連しています.

研究 の 目的:

  • LEL酸性化とその関連性,および全身性ループス・エリテマトサス (SLE) の疾患活動およびバイオマーカーを調査する.

主な方法:

  • SLE患者とネズミのモデル (MRL/lprマウス) の横断研究.
  • LEL酸化,表面結合核細胞,IgG-免疫複合体 (IgG-IC) の蓄積に関する分析.
  • PI3k,SHP-1,SHIP-1を含むメカニズム的な経路が調査されています.

主要な成果:

  • SLE患者では,LEL酸化が低下し,免疫細胞の表面核細胞蓄積が増加している.
  • アクティブなSLEは,LEL酸化障害とIgG-ICエクソサイトーシスと相関しています.
  • ネズミのモデルと特定の分子欠陥 (SHP-1,SHIP-1) は,LEL機能不全を再現します.
  • 非酸性LELは,SLE患者の67%で発見され,特定の臨床症状 (関節炎,発疹,腎炎) と関連しています.

結論:

  • LEL機能不全は,SLEにおける頻繁な発見であり,活発な疾患と特定の臨床的特徴に関連しています.
  • LEL機能障害は,SLE.の独特のエンドタイプを表す可能性があります.
  • LEL機能障害は,SLE患者層分化の貴重なバイオマーカーとして機能する可能性があります.