関連する実験動画

Updated: Feb 19, 2026

Evaluating Therapeutic Interventions in the SHIP-deficient Mouse Model of Crohn Disease-like Ileitis and Fibrosis
09:44

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Published on: October 14, 2025

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後期エンドソーム/ライソーム機能の低下は,慢性PI3k活動とSHP-1/SHIP-1欠陥を通してSLEを促進する

SunAh Kang1, Andrew J Monteith1, Liubov Arbeeva2

  • 1Department of Microbiology and Immunology, University of North Carolina, Chapel Hill, United States of America.

JCI insight
|February 17, 2026
PubMed
まとめ

システミック・ルプス・エリテマトーサス (SLE) 患者では,末期のエンドソームとリゾソーム (LEL) の酸化が低下し,細胞廃棄物の蓄積と免疫複合体の蓄積につながる. この機能障害は,特定のSLE疾患のバイオマーカーとして機能する可能性があります.

キーワード:
自己免疫性疾患は自己免疫性疾患である.自己免疫とは,自己免疫である.免疫学 免疫学とは狼 (ルプス) とはライソソームはライソソームである.

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