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Updated: Feb 19, 2026

Development of Inhibitors of Protein-protein Interactions through REPLACE: Application to the Design and Development Non-ATP Competitive CDK Inhibitors
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サイクリン依存キナーゼ (CDK) 7阻害剤BS-181は病原性Cryptococcus種を抑制し,G2/M停止とスプライシング欠陥を引き起こす

Pooja Sethiya1,2, Desmarini Desmarini1,2, Bethany Bowring1,2

  • 1Centre for Infectious Diseases and Microbiology, Westmead Institute for Medical Research, Westmead, NSW , Australia.

Virulence
|February 17, 2026
PubMed
まとめ

抗癌薬BS-181は,サイクリン依存キナーゼ7 (CDK7) を阻害することによって,Cryptococcusに対する抗真菌活性を示しています. BS-181とアンフォテリシンBの併用療法により,前臨床モデルでは真菌感染症に対する保護が強化されています.

キーワード:
BS-181 についてCDK7阻害剤であるCDK7阻害剤であるクリプトコッカス・ガッティ (Cryptococcus gattii) とはクリプトコッカス・ネオフォーマンス (Cryptococcus neoformans) とは抗真菌剤は,抗真菌剤として使われています.細胞循環の細胞周期についてです.スプライシング (splicing) とはトランスクリプション トランスクリプション翻訳 翻訳 翻訳 翻訳

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