Jove
Visualize
お問い合わせ
JoVE
x logofacebook logolinkedin logoyoutube logo
JoVEについて
概要リーダーシップブログJoVEヘルプセンター
著者向け
出版プロセス編集委員会範囲と方針査読よくある質問投稿
図書館員向け
推薦の声購読アクセスリソース図書館諮問委員会よくある質問
研究
JoVE JournalMethods CollectionsJoVE Encyclopedia of Experimentsアーカイブ
教育
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab Manual教員リソースセンター教員サイト
利用規約
プライバシーポリシー
ポリシー

関連する概念動画

Cancer02:18

Cancer

Cancers arise due to mutations in genes involved in the regulation of cell division, which leads to unrestricted cell proliferation. Modern science and medicine have made great strides in the understanding and treatment of cancer, including eradicating cancer in some patients. However, there is still no cure for cancer. This is largely due to the fact that cancer is a large group of many diseases.
Mutations01:39

Mutations

Overview
Comparing Copy Number Variations and SNPs02:26

Comparing Copy Number Variations and SNPs

Sequencing of the human genome has opened up several best-kept secrets of the genome. Scientists have identified thousands of genome variations that exist within a population. These variations can be a single nucleotide or a larger chromosomal variation.
Copy number variations or CNVs are the structural variations that cover more than 1kb of DNA sequence. The single nucleotide polymorphism (SNP), on the other hand, is a single nucleotide change or a point mutation that is found in more than 1%...
In vitro Mutagenesis01:16

In vitro Mutagenesis

To learn more about the function of a gene, researchers can observe what happens when the gene is inactivated or “knocked out,” by creating genetically engineered knockout animals. Knockout mice have been particularly useful as models for human diseases such as cancer, Parkinson’s disease, and diabetes.
Cancer-Critical Genes II: Tumor Suppressor Genes01:05

Cancer-Critical Genes II: Tumor Suppressor Genes

Genes usually encode proteins necessary for the proper functioning of a healthy cell. Mutations can often cause changes to the gene expression pattern, thereby altering the phenotype.
When the function of certain critical genes, especially those involved in cell cycle regulation and cell growth signaling cascades, gets disrupted, it upsets the cell cycle progression. Such cells with unchecked cell cycles start proliferating uncontrollably and eventually develop into tumors.
Such genes that act...
Genetic Variation01:25

Genetic Variation

Genetic variation is the diversity in DNA sequences found among individuals of the same species. This diversity is crucial for a species' survival because it helps organisms adapt to environmental changes. Genetic variation begins with fertilization, where an egg and sperm cell merge. Each of these cells carries 23 chromosomes, up to 46 in the fertilized egg. Chromosomes are long DNA strands that contain genes, the basic units of heredity.
Genes exist in different versions called alleles, which...

こちらも読む

関連記事

共著者、ジャーナル、引用グラフによってこの研究に関連する記事。

並び替え
Same author

Adenosine drives suppression of CD16low NK cell responses against HGSC via NKG2A:hLA-E interactions.

Journal of leukocyte biology·2026
Same author

Preoperative Soluble AXL in Plasma Predicts Futility of Resecting Pancreatic Ductal Adenocarcinoma.

Current oncology (Toronto, Ont.)·2026
Same author

Effective allogeneic natural killer cell therapy for pancreatic adenocarcinoma avails conserved activating receptors and evades HLA I-driven inhibition.

Journal for immunotherapy of cancer·2026
Same author

Persistent glycolysis defines pathological foreign body-associated inflammation to polymeric implants.

Science advances·2025
Same author

Canadian National Pancreas Conference 2023: A Review of Multidisciplinary Engagement in Pancreatic Cancer Care.

Current oncology (Toronto, Ont.)·2024
Same author

BioCanRx Summit for Cancer Immunotherapy 2022 Proceedings.

Biochemistry and cell biology = Biochimie et biologie cellulaire·2023
Same journal

DeepMethylation: A deep learning framework for tissue-specific DNA methylation prediction and functional variant annotation.

PLoS computational biology·2026
Same journal

Redefining and estimating the early-phase reproduction ratio for epidemic outbreaks in spatially structured populations.

PLoS computational biology·2026
Same journal

Optimized phenotype definitions boost GWAS power.

PLoS computational biology·2026
Same journal

Detection, communication, and individual identification with deep audio embeddings: A case study with North Atlantic right whales.

PLoS computational biology·2026
Same journal

Exploring the structural lexicon of the Proteome via Metric Geometry.

PLoS computational biology·2026
Same journal

Linking retinal sampling in neural encoding models to temporal profiles of visual processing in humans.

PLoS computational biology·2026
関連記事をすべて見る

関連する実験動画

Updated: May 14, 2026

Simple and Rapid Method to Obtain High-quality Tumor DNA from Clinical-pathological Specimens Using Touch Imprint Cytology
11:20

Simple and Rapid Method to Obtain High-quality Tumor DNA from Clinical-pathological Specimens Using Touch Imprint Cytology

Published on: March 21, 2018

11.4K

腫瘍サンプルにおける変種尋問のためのチュートリアル.

Riley J Arseneau1,2, Leah K MacLean1,2, Jeanette E Boudreau1,2,3

  • 1Department of Pathology, Dalhousie University, Halifax, Nova Scotia, Canada.

PLoS computational biology
|February 17, 2026
PubMed
まとめ
この要約は機械生成です。

このフレームワークは,次世代のシーケンシングを使用して,がんの体的変異分析を簡素化します. これは,再現可能で臨床的に重要な発見のための計画,資源収集,フィルタリング,拡散を通じて研究者を導く.

さらに関連する動画

Visualizing Genetic Variants, Short Targets, and Point Mutations in the Morphological Tissue Context with an RNA In Situ Hybridization Assay
10:57

Visualizing Genetic Variants, Short Targets, and Point Mutations in the Morphological Tissue Context with an RNA In Situ Hybridization Assay

Published on: August 14, 2018

11.2K
Comparative Lesions Analysis Through a Targeted Sequencing Approach
08:16

Comparative Lesions Analysis Through a Targeted Sequencing Approach

Published on: November 5, 2019

7.3K

関連する実験動画

Last Updated: May 14, 2026

Simple and Rapid Method to Obtain High-quality Tumor DNA from Clinical-pathological Specimens Using Touch Imprint Cytology
11:20

Simple and Rapid Method to Obtain High-quality Tumor DNA from Clinical-pathological Specimens Using Touch Imprint Cytology

Published on: March 21, 2018

11.4K
Visualizing Genetic Variants, Short Targets, and Point Mutations in the Morphological Tissue Context with an RNA In Situ Hybridization Assay
10:57

Visualizing Genetic Variants, Short Targets, and Point Mutations in the Morphological Tissue Context with an RNA In Situ Hybridization Assay

Published on: August 14, 2018

11.2K
Comparative Lesions Analysis Through a Targeted Sequencing Approach
08:16

Comparative Lesions Analysis Through a Targeted Sequencing Approach

Published on: November 5, 2019

7.3K

科学分野:

  • ゲノミクスゲノミクスとは
  • がん研究 がん研究
  • バイオインフォマティックス

背景:

  • 次世代シーケンシング (NGS) は,がんにおける体変異の検出を可能にします.
  • 変数分析パイプラインは,複雑さとツール選択により,大きな障壁を提示します.
  • 研究者,特に翻訳の分野では,アクセシブルなガイドラインが必要です.

研究 の 目的:

  • 腫瘍サンプルにおける体的変異尋問をナビゲートするための実用的な枠組みを提供すること.
  • 癌変異分析における複雑性とアクセシビリティの課題に対処するため.
  • 腫瘍のシーケンシングデータを分析する自信と厳格性を高めるために.

主な方法:

  • 4段階の枠組み:計画,資源の収集,フィルタリングと検証,拡散と保存.
  • 実験設計,ツールアセンブリ,変種優先順位付け,データ共有を重視する.
  • アクセシビリティ,再現性,および臨床的関連性に焦点を当てます.

主要な成果:

  • 変種分析の重要なステップを通して研究者を導くための構造化されたアプローチ.
  • アウトプットのシーケンスを理解し,必要なリソースの選択を容易にします.
  • 有意義な変種識別のための体系的なフィルタリングと検証を可能にします.

結論:

  • このフレームワークにより,研究者はソマティック変異分析を自信を持って行うことができます.
  • 透明な報告とデータ共有を通じて,再現可能で臨床的に重要ながん研究を促進します.
  • さまざまな研究環境における変異分析における障壁を克服するのに役立つ.