側向化された感覚信号伝達経路は,Caenorhabditis elegansの文脈依存の嗅覚の可塑性を媒介する

Anjali Pandey¹, Maya Katz¹, Stephen Nurrish¹

¹Department of Biology, Brandeis University, Waltham, MA 02454.

Proceedings of the National Academy of Sciences of the United States of America

|February 17, 2026

まとめ

C. elegansの行動の柔軟性は,神経の可塑性に依存しています. この研究は,嗅覚ニューロンの非対称な分子機構が対称な行動応答を駆動し,適応力を高めることを明らかにしています.

科学分野:

神経科学は神経科学である.
分子生物学は分子生物学である.
行動遺伝学行動遺伝学

背景:

神経機能の横行化は,行動の柔軟性にとって極めて重要です.
C. elegansの文脈依存性可塑性には,双方のAWC嗅覚ニューロンにおける対称的な匂い反応の逆転が含まれています.

研究の目的:

シンメトリックニューロン応答の可塑性の基礎にある分子機構を調査する.
非対称な分子メカニズムが,対称な行動の可塑性をどのように誘導するかを決定する.

主な方法:

C. elegans. のガニリルサイクラース受容体12 (GCY-12) の遺伝子操作
AWC^OFFおよびAWC^ONニューロンの匂い誘発反応の分析.
レスポンスの可塑性におけるAWCの運命横向化の役割の調査.

主要な成果:

gcy-12の変異は,AWC^OFFニューロンの匂い反応の可塑性を特に廃止する.
gcy-12変異体のAWC^OFFおよびAWC^ONニューロンの非対称な匂い誘発反応の兆候は,行動的無関心につながります.
GCY-12は,可塑性調節のためにAWCニューロンの両方で必要ですが,主にAWC^OFFに影響します.
AWCの運命の横向化を妨害することで,gcy-12変異体における応答可塑性の非対称性が排除されます.

結論:

シンメトリックなニューロン応答の可塑性は,非対称な分子機構から生じる可能性があります.
信号伝達経路の横行化は,神経および行動の柔軟性を高めることができます.

キーワード:

C.エレガンス (C. elegans) とはガニリルサイクラゼは,ガニリルサイクラゼを左と右の非対称性嗅覚は,嗅覚を感じるものです.プラスティシティプラスティシティ

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