関連する実験動画

Updated: Feb 19, 2026

A Phenotyping Regimen for Genetically Modified Mice Used to Study Genes Implicated in Human Diseases of Aging
09:37

A Phenotyping Regimen for Genetically Modified Mice Used to Study Genes Implicated in Human Diseases of Aging

Published on: July 14, 2016

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哺乳類のAHR2喪失:進化のパターン,メカニズム,および生物学的要因の関連性

Woo-Seon Song1, Dong-Hee Koh1, Dong Ha Kim2

  • 1Department of Biomedical and Pharmaceutical Sciences, Kyung Hee University, Hoegi-Dong, Dongdaemun-Gu, Seoul 130-701, Korea.

Ecotoxicology and environmental safety
|February 17, 2026
PubMed
まとめ

哺乳類は,高代謝などの進化的圧力により,ダイオキシン感受性の重要な要因であるAHR2遺伝子を独特に失いました. これは,哺乳類が特定の環境汚染物質に対して敏感性が低い理由を説明します.

キーワード:
アリル炭化水素受容体 アリル炭化水素受容体は,ディオキシンの毒性遺伝子の喪失 進化リスク評価 リスク評価種の感受性 種の感受性野生生物の毒性学について

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Engineering Oncogenic Heterozygous Gain-of-Function Mutations in Human Hematopoietic Stem and Progenitor Cells12:04

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Mismatch Repair01:20

Mismatch Repair

Organisms are capable of detecting and fixing nucleotide mismatches that occur during DNA replication. This sophisticated process requires identifying the new strand and replacing the erroneous bases with correct nucleotides. Mismatch repair is coordinated by many proteins in both prokaryotes and eukaryotes.
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The human genome has more than 3 billion base pairs of DNA per cell. Prior to cell division, that vast amount of genetic...
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Mismatch Repair

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Multi-species Conserved Sequences

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Although the genome of each species varies greatly from each other, a few sequences are highly conserved. Such conserved...
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Exon Recombination02:32

Exon Recombination

The evolution of new genes is critical for speciation. Exon recombination, also known as exon shuffling or domain shuffling, is an important means of new gene formation. It is observed across vertebrates, invertebrates, and in some plants such as potatoes and sunflowers. During exon recombination, exons from the same or different genes recombine and produce new exon-intron combinations, which might evolve into new genes. 
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Gene Conversion

Other than maintaining genome stability via DNA repair, homologous recombination plays an important role in diversifying the genome. In fact, the recombination of sequences forms the molecular basis of genomic evolution. Random and non-random permutations of genomic sequences create a library of new amalgamated sequences. These newly formed genomes can determine the fitness and survival of cells. In bacteria, homologous and non-homologous types of recombination lead to the evolution of new...
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Hardy-Weinberg Principle01:49

Hardy-Weinberg Principle

Diploid organisms have two alleles of each gene, one from each parent, in their somatic cells. Therefore, each individual contributes two alleles to the gene pool of the population. The gene pool of a population is the sum of every allele of all genes within that population and has some degree of variation. Genetic variation is typically expressed as a relative frequency, which is the percentage of the total population that has a given allele, genotype or phenotype.
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