FDM 3Dプリンティングによるパーソナライズされた口服薬の投与:シリコインモデリングでサポートされる調節可能な放出プロファイルを持つポリビニルアルコールカプセル
Haya Khader Ahmad Yasin1, Moawia M Al-Tabakha2, Siok Yee Chan3
1School of Pharmaceutical Sciences, Universiti Sains Malaysia, 11800, Pulau Pinang, Malaysia; Department of Pharmaceutical Sciences, College of Pharmacy and Health Sciences, Ajman University, Ajman, United Arab Emirates; Centre of Medical and Bio-allied Health Sciences Research Centre, Ajman University, Ajman, UAE.
まとめ
フューズドデポジションモデリング (FDM) 3Dプリントにより,カスタマイズされた経口薬の投与が可能になります. カプセルの幾何学と密度を調整することで,研究者はパーソナライズされた医薬品の薬物放出プロフィールを制御しました.
科学分野:
- 医薬品技術 医薬品技術について
- マテリアルサイエンス 材料科学
- バイオメディカルエンジニアリング
背景:
- 3DプリントによるFused Deposition Modeling (FDM) は,パーソナライズされた医薬品製造の可能性を秘めています.
- 薬物の放出が制御され,適切な機械的特性を持つ印刷可能なフィラメントの開発は,依然として課題です.
研究 の 目的:
- 調節可能な薬物放出プロファイルを持つパーソナライズされたカプセルを作成するためにFDM3Dプリントの使用を調査する.
- カプセル幾何学と内部密度の薬剤放出運動に対する影響を調査する.
主な方法:
- ケトプロフェンをポリビニールアルコール (PVA) のカプセルシェルに調製し,FDM印刷に使用する.
- カプセル殻の幾何学と内部密度の体系的な変化.
- 薬局品質試験,溶解試験,マイクロコンピュータトモグラフィー (Micro-CT),およびシリコ製薬動態シミュレーションを用いた評価.
主要な成果:
- カプセルの幾何学とポリマーの選択は,薬剤の放出率を著しく調節しました.
- 下の殻/充填密度では即時放出 (IR) が加速され,高い密度では持続放出 (SR) が延長された.
- マイクロCTは設計に関連した孔性の違いを確認し,シミュレーションはIRおよびSR製剤の異なるプラズマプロフィールを予測しました.
結論:
- FDM 3Dプリントは,幾何学的な設計を通じて口服薬の放出を調節するための柔軟なプラットフォームを提供します.
- FDM印刷と組み合わせたインシリコツールは,カスタマイズされた薬物投与システムを設計するための枠組みを提供します.
- このアプローチは,放出特性を合わせたパーソナライズド医薬品の開発を容易にする.
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