HIVと心血管疾患:体系的なレビューと比較リスク評価研究

Zeyu Luo^1,2, Ke Tang^1,2, Jiayao Ying^1,2

¹Center for Clinical Big Data and Statistics of the Second Affiliated Hospital Zhejiang University School of Medicine, School of Public Health Zhejiang University School of Medicine, Hangzhou, China.

BMJ global health

|February 17, 2026

まとめ

HIVに起因する心血管疾患 (CVD) の負担は,世界的に,特にアフリカ地域において,著しく増加しています. CVDスクリーニングをHIVケアに統合することは,特に高流行地域では極めて重要です.

科学分野:

エピデミオロジーエピデミオロジー
公衆衛生は公衆衛生である.
感染症感染症は感染症です.

背景:

HIV感染者 (PLWH) は,心血管疾患 (CVD) のリスクがかなり高くなります.
HIVに起因するCVDの時間的傾向と負担を理解することは,公衆衛生の介入にとって非常に重要です.

研究の目的:

HIV感染に起因する心血管疾患 (CVD) の負担における世界,地域,および国の時間的傾向を定量化する.
CVDの様々なサブタイプに対するHIVの影響を評価する.

主な方法:

コホート研究 (PubMed,Embase,MEDLINE) の体系的な文献検索は2024年10月まで実施する.
HIVとCVDの総合リスク比率 (RRs) を推定するためのランダム効果メタアナリシス.
2021年の世界疾病負担 (GBD) データ (2000-2021) を用いて,人口帰属分数 (PAFs) と年齢標準化されたDALYs率 (ASDRs) の計算.

主要な成果:

HIV感染は,全CVD (RR=1.38),脳卒中 (1.90),缺血性心臓病 (1.72),心停止 (2.58) のリスクを大幅に増加させる.
HIVに起因する世界的なCVDの負担は2000年から2021年の間にほぼ3倍に増加し,人口10万人に3.45から9.26に増加しました.
この負担は,社会人口指数が低い地域,特に南アフリカで最も高く,レソトとエスワチニは2021年に最も高い割合を示しています.

結論:

HIVに起因するCVDの負担は,過去20年間に大幅に増加しました.
この負担はアフリカ地域に顕著に集中しています.
CVDのスクリーニングと管理をHIVケアに統合することは,高い流行率の環境で緊急に必要とされています.

キーワード:

心血管疾患は,心血管疾患である.グローバル・ヘルスグローバル・ヘルス HIVはHIVを感染する.システマティック・レビューシステマティック・レビュー

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