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Updated: Feb 19, 2026

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ドーピングとアンチドーピングを理解する:一般小児科医のためのガイド

Mary Beatrix Cohen1, Rachel Jenner2

  • 1General Paediatrics, Royal Manchester Children's Hospital, Manchester, UK MaryBeatrix.Cohen@mft.nhs.uk.

Archives of disease in childhood. Education and practice edition
|February 17, 2026
PubMed
まとめ

イメージとパフォーマンスを高める薬物 (IPED) とサプリメントは,若者によってますます使用されています. 小児科医は,IPEDやサプリメントに関連する潜在的なリスクを特定,調査,管理するためのガイドラインを必要としています.

キーワード:
青少年の健康について心臓病学 心臓病学エンドクリノロジー エンドクリノロジーメンタルヘルス メンタルヘルス

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In pediatric care, understanding the nuances of hepatic drug metabolism is crucial, as it significantly differs from that of adults. This divergence is primarily due to the developmental stage of drug-metabolizing enzymes, which affects how medications are processed in the body. In neonates, for instance, the activity of Phase I enzymes—critical for the initial breakdown of drugs—is markedly reduced, functioning at just 20–40% of the levels seen in adults. This reduction poses...
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Understanding the physiological differences in the pediatric population is crucial for effective pharmacotherapy. Neonates, infants, and children exhibit significant variations in gastric pH, gastric emptying time, intestinal transit time, and biliary function. These variations profoundly affect oral drug absorption, necessitating a nuanced approach to pediatric dosing.Neonates present with a unique physiological profile, having a gastric pH greater than 4 and faster and more irregular gastric...
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