COVID-19のロックダウン期間中の精神的苦痛の家族内ダイナミクス
Johanne H Pettersen1,2, Espen Eilertsen3, Laura Hegemann4,5
1PsychGen Center for Genetic Epidemiology and Mental Health, Norwegian Institute of Public Health, Oslo, Norway. johannehagen.pettersen@fhi.no.
Translational psychiatry
|February 17, 2026
まとめ
家族の遺伝的要因は,特にCovid-19のロックダウン中に,精神的苦痛に影響を与えます. 間接的な遺伝的影響は,青春期の苦痛 (母親によって引き起こされる) と親の苦痛 (子供によって引き起こされる,またはパートナーによって引き起こされる) を説明する.
科学分野:
- 行動遺伝学 行動遺伝学
- 精神科医は精神病を患っている.
- エピデミオロジー エピデミオロジー
背景:
- Covid-19 パンデミックと関連するロックダウンにより,家族の近接と曝露が増加しました.
- この期間の精神的苦痛に対する家族の具体的な貢献は不明である.
- 家族内の遺伝的影響を理解することは,精神衛生研究にとって極めて重要です.
研究 の 目的:
- COVID-19のロックダウン期間中の精神的苦痛に対する親主導,子主導,パートナー主導の遺伝的貢献を分別する.
- 核家族における精神的苦痛に対する直接的・間接的な遺伝的影響を調査する.
- 精神疾患のポリジェニックスコア (PGS) と家族の苦痛との関連を調べる.
主な方法:
- 青少年,母親,父親の遺伝データを用いてトリオゲノム全体にわたる複雑な特性の分析を行いました.
- 遺伝的責任因子とその時間的安定性を評価するためにトリオポリジェニックスコア (PGS) 設計を採用しました.
- 直接的な遺伝的影響 (個人の遺伝子型が自身の苦痛に及ぼす影響) と間接的な遺伝的影響 (個人の遺伝子型が家族の苦痛に及ぼす影響) に関する多様性成分を分析した.
主要な成果:
- 間接的な遺伝的影響は,青少年の精神的苦痛の10% (母親によって引き起こされる) と父親の苦痛の5% (子供によって引き起こされる) を占めた.
- パートナー主導の間接的な遺伝効果は,母親の精神的苦痛の2-3%を説明しました.
- 母親のうつ病とADHDのポリジェニックスコアは,父親の精神的苦痛と関連しており,直接的な遺伝的影響は,不安,うつ病,ADHD,神経症と関連した苦痛の変異の9-10%を説明しました.
結論:
- 家族レベルの遺伝的要因が精神的苦痛に大きく貢献し,母親から青少年,子供から父親への間接的な影響が顕著である.
- 一般的な精神疾患の変異によって部分的に説明される直接的な遺伝的影響も,個人の精神的苦痛において重要な役割を果たしています.
- 発見は,メンタルヘルスにおける家族のダイナミクスの重要性を強調し,家族を介入に含めることの潜在的な利点を示唆しています.
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