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Updated: Feb 19, 2026

Isolation and Quantification of Epstein-Barr Virus from the P3HR1 Cell Line
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エプスタイン・バーウイルス核抗原1は,免疫療法に対するADAR1主導の腫瘍耐性を誘発する

Changlin Liu1,2, Zhiqiang Sun3,4, Chao Li5

  • 1Shenzhen Key Laboratory of Viral Oncology, Shenzhen Hospital of Southern Medical University, Guangdong, China.

Signal transduction and targeted therapy
|February 17, 2026
PubMed
まとめ

エプスタイン・バーウイルスのタンパク質EBNA1は,RNA編集を強化し,インターフェロン反応を阻害することによって,抗腫瘍免疫を抑制する. EP-1215でEBNA1を標的にすると,免疫が回復し,チェックポイントブロック治療に対する反応が改善されます.

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