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Updated: Feb 19, 2026

Author Spotlight: Enhancements in Gene Expression Regulation Research
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ヒストンデメチラーゼKDM4BはNLRP3発現をエピジェネティックに制御し,炎症反応を強化する

Li Tong1, Hui Song1,2, Yuan Gao1

  • 1Key Laboratory of Infection Immunity and Disease Intervention of Shandong Province, and Key Laboratory for Experimental Teratology of the Chinese Ministry of Education, School of Basic Medical Science, Cheeloo College of Medicine, Shandong University, Jinan, Shandong, China.

EMBO molecular medicine
|February 17, 2026
PubMed
まとめ

ヒストン脱甲基酵素KDM4Bは,H3K9me3のマークを取り除き,新しい抗炎症標的を提供することによって,NLRP3炎症体の活性化を加速します. 高血糖は,このプロセスを悪化させ,感染中に炎症を悪化させます.

キーワード:
エピジェネティック・モディフィケーションH3K9me3は3つにまとめました.KDM4Bは,KDM4Bで,KDM4Bは,KDM4Bで,KDM4Bは,KDM4Bで,KDM4Bは,KDM4Bで,KDM4Bは,KDM4BでNLRP3は,NLRP3を,NLRP3を,NLRP3を,NLRP3を,NLRP3を,NLRP3を,NLRP3を,NLRP3を,NLRP3を,NLRP3を,NLRP3を,NLRP3をNLRP3 インフラマソーム炎症

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