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Updated: Feb 19, 2026

Deciphering High-Resolution 3D Chromatin Organization via Capture Hi-C
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ゲノムを拡大したスケールと解像度でアノテーションする

Hyun Joo Ji1,2, Mihaela Pertea1,2,3, Steven L Salzberg4,5,6,7

  • 1Center for Computational Biology, Johns Hopkins University, Baltimore, MD, USA.

Nature reviews. Genetics
|February 17, 2026
PubMed
まとめ

ゲノムアノテーションはDNAの機能的要素をカタログ化し,遺伝子と疾患の研究を改善します. 配列と計算方法の進歩は,自動化されたゲノムアノテーションシステムを強化しています.

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While every living organism has a genome of some kind (be it RNA, or DNA), there is considerable variation in the sizes of these blueprints. One major factor that impacts genome size is whether the organism is prokaryotic or eukaryotic. In prokaryotes, the genome contains little to no non-coding sequence, such that genes are tightly clustered in groups or operons sequentially along the chromosome. Conversely, the genes in eukaryotes are punctuated by long stretches of non-coding sequence.
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