自己免疫性神経炎症は,MIF核酵素媒介型パーサナトス経由でニューロンの死につながる

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Updated: Feb 19, 2026

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Jackson W Mace1,2,3, Sachin P Gadani1,4, Matthew D Smith1

  • 1Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD, USA.

Nature neuroscience
|February 17, 2026
PubMed
まとめ

中枢神経系の炎症は,多発性硬化症のような疾患で神経変性を引き起こす. この研究は,細胞死経路であるパルタナトスをマウスモデルにおけるニューロン喪失の重要な要因として特定し,新しい治療標的を提供している.

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