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腸内皮質Smad7は, purinの代謝失調とイレアル炎症を誘発する

Federica Laudisi1, Mattia Alberto Serra1, Lorenzo Tomassini1

  • 1Department of Systems Medicine, University of Rome Tor Vergata, Rome, Italy.

Journal of biomedical science
|February 18, 2026
PubMed
まとめ

腸内皮質細胞におけるSmad7の過剰発現は, purinの代謝を妨害し,アデノシンを下げることによって,イレアル損傷を引き起こす. アデノシンレベルを回復すると,この炎症が軽減され,炎症性腸疾患の新たな治療標的が示唆されます.

キーワード:
クローン病は,クローン病である.IBD IBD IBD IBD IBD IBD IBD IBD IBD IBD IBD IBD IBD IBD IBD IBDムコサール免疫TGF-βはTGF-βと一致している.潰瘍性大腸炎 (Ulcerative colitis) とは 潰瘍性大腸炎 (Ulcerative colitis) とは 潰瘍性大腸炎 (Ulcerative colitis) とは 大腸炎 (Ulcerative colitis) とは

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