前立腺がんのための食事,栄養,ホルモン療法:将来の介入への意味を持つ体系的なレビュー
Isabella Pahulu1, Matthew Calumpit2, Paul Tominez3
1Department of Epidemiology and Population Health, Stanford University, Stanford, CA, USA.
JNCI cancer spectrum
|February 18, 2026
まとめ
ダイエット介入と体重管理戦略は,前立腺がん患者のアンドロゲン欠乏療法 (ADT) の副作用を軽減するのに役立ちます. これらの栄養学的アプローチは,生存者ケア中に代謝の健康と生活の質を改善します.
科学分野:
- 腫瘍学 腫瘍学
- 栄養科学 栄養学 栄養科学は,栄養学が,栄養学が,栄養学が,栄養学が,栄養学が,栄養学が,栄養学が,栄養学が,栄養学が,栄養学が,栄養学は,栄養学が,栄養学は,栄養学は,栄養学は,栄養学は,栄養学は,栄養学は,栄養学は,栄養学は,栄養学は,栄養学は
- メタボリック・ヘルス (代謝の健康)
背景:
- アンドロゲン欠乏療法 (ADT) は前立腺がんの治療に不可欠ですが,代謝症候群のような副作用を引き起こす.
- 併発症の管理は,ADTを受ける前立腺がん患者の生存に不可欠です.
- ADT関連代謝症候群には,グルコース耐性の低下,筋肉質の減少,体重増加が含まれています.
研究 の 目的:
- ダイエットと体重管理の介入に関するランダム化臨床試験 (RCT) を,ADT関連の副作用について体系的にレビューする.
- 前立腺がん患者の生活の質と代謝健康に対する栄養戦略がADTに与える影響を評価する.
主な方法:
- PRISMAのガイドラインを用いて,2015年から2025年の間に発表されたRCTの体系的なレビュー.
- "前立腺がん"",ダイエット"",栄養"",GLP-1RA"",ADT"など,PubMed/Embaseで検索した.
- ROB2とGRADEツールを使用してRCTの質を評価しました.
主要な成果:
- 16件のRCTは基準を満たしており,GLP-1RAを評価したり,バイアスのリスクが高かったりしたものはありませんでした.
- 地中海と低炭水化物ダイエットと運動を組み合わせると,代謝の危険因子を軽減します.
- 多学科ケアとコミュニティサポートにより,アデバーンスが強化され,長期的な成果が得られました.
結論:
- ADTを受けている前立腺がん患者にとって,栄養介入は安全で実行可能である.
- 生存者の介護のために,食事戦略を推奨することができます.
- 将来の研究は,最適な食事の持続時間,より長いフォローアップ,およびGLP-1RAのような新しい治療法に焦点を当てなければなりません.
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