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Updated: Feb 19, 2026

Technical Aspect of the Automated Synthesis and Real-Time Kinetic Evaluation of [11C]SNAP-7941
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(N) -メタノカルバアデノシン誘導体は,P-グリコタンパク質とABCG2トランスポーターの二重調節剤として用いられる

Megumi Murakami1, Dilip K Tosh2, Paula B Salazar1

  • 1Laboratory of Cell Biology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892, United States.

Journal of medicinal chemistry
|February 18, 2026
PubMed
まとめ

研究者らは,多剤耐性 (MDR) を標的とした新しいヌクレオシドアナログを開発した. 化合物30はABCG2を阻害し,がん細胞を感知させ,化合物16は二重阻害剤として作用し,がん薬剤耐性に対する新しい戦略を提供します.

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