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Updated: Feb 19, 2026

Method for Measuring the Activity of Deubiquitinating Enzymes in Cell Lines and Tissue Samples
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Published on: May 10, 2015

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デウビキチナゼUSP2は,p300の安定化により,肝臓のステラ細胞の活性化を促進する

Seunghee Byun1, Hyunsik Kim1, Sun-Ho Lee1

  • 1Department of Biochemistry and Molecular Biology, Severance Medical Research Institute, Graduate School of Medical Science, Brain Korea 21 Project, Yonsei University College of Medicine, Seoul, South Korea.

FEBS letters
|February 18, 2026
PubMed
まとめ

研究者らは,USP2が肝繊維症の重要な要因であるp300を安定させることを発見しました. USP2を阻害すると,このメカニズムを標的とし,肝臓の傷を軽減し,肝臓疾患に対する新しい治療戦略を提供します.

キーワード:
デウビキチナーションとは肝臓のステラ細胞とは肝臓線維症 肝臓線維症 肝臓線維症USP2は,USP2で,USP2は,USP2でp300からp300まで

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