関連する実験動画

Updated: Feb 19, 2026

Cell Population Analyses During Skin Carcinogenesis

Cell Population Analyses During Skin Carcinogenesis

Published on: August 21, 2013

基礎細胞癌の管理におけるパラダイムの進化

Gerardo Palmisano^1,2, Daniele Omar Traini^1,2, Francesco Brunetti^1,2

¹UOC di Dermatologia, Dipartimento di Scienze Mediche e Chirurgiche.

Current opinion in oncology

|February 18, 2026

まとめ

先進的な基礎細胞癌 (BCC) 治療には,ヘッジホッグ経路阻害剤と免疫療法が統合されています. 新しい戦略は精密腫瘍学に焦点を当て,ターゲットを絞った治療法,免疫チェックポイントの封鎖,およびよりよい結果のための高度なイメージングを組み合わせています.

科学分野:

腫瘍学腫瘍学
皮膚科皮膚科について

背景:

基礎細胞癌 (BCC) は,世界的に最も一般的な皮膚がんです.
手術で治療できる場合が多いが,進行または転移したBCCには全身治療が必要である.

研究の目的:

先進的な基礎細胞癌の全身的管理における最近の進歩をレビューする.
新しい治療法とイメージング技術の臨床実務への影響を議論する.

主な方法:

ヘッジホッグ経路阻害剤 (HHI) と免疫チェックポイント阻害 (例えばPD-1阻害剤) に関する最新の証拠のレビュー.
新興の局所的,新補助的,および手術後の治療戦略の分析.
評価とモニタリングのための高度なイメージング技術の検討.

主要な成果:

ヘッジホッグ経路阻害剤は,先進的なBCCのファーストライン療法として確認されています.
プログラム死亡-1 (PD-1) ブロックは,HHIの失敗後の持続的な反応を示し,早期使用の可能性があります.
新興戦略は,機能的保存,手術前評価の改善,応答のモニタリングに焦点を当てています.

結論:

近代的なBCC管理は,精密腫瘍学モデルへ移行しています.
分子標的化,免疫療法,および高度なイメージングの統合は,治療の配列と手術の役割を再定義しています.

キーワード:

ベースセル癌 (ベースセルがん) が発症する.セミピリマブ (セミピリマブ) とは,セミピリマブ (セミピリマブ) とは,セミピリマブ (セミピリマブ) とは,セミピリマブ (セミピリマブ) とは,セミピリマブ (セミピリマブ) とは,セミピリマブ (セミピリマブ) とはヘッジホッグ経路阻害剤は,ヘッジホッグ経路阻害剤として使用されています.免疫療法による免疫療法ネオアドジュバント (neoadjuvant) とは

さらに関連する動画

A 3D Organotypic Melanoma Spheroid Skin Model

A 3D Organotypic Melanoma Spheroid Skin Model

Published on: May 18, 2018

Combining Reflectance Confocal Microscopy with Optical Coherence Tomography for Noninvasive Diagnosis of Skin Cancers via Image Acquisition

Combining Reflectance Confocal Microscopy with Optical Coherence Tomography for Noninvasive Diagnosis of Skin Cancers via Image Acquisition

Published on: August 18, 2022

関連する概念動画

Skin Cancer

Skin Cancer

Skin cancer is a type of cancer that occurs when there is an abnormal growth of skin cells, usually triggered by damage to the DNA within the skin cells. It is primarily caused by exposure to ultraviolet (UV) radiation from the sun or artificial sources like tanning beds. Skin cancer is the most common type of cancer worldwide, and its incidence continues to rise.
Basal Cell Carcinoma (BCC): BCC is the most common type of skin cancer, accounting for about 80% of cases. It typically develops in...

Tumor Progression

Tumor Progression

Tumor progression is a phenomenon where the pre-formed tumor acquires successive mutations to become clinically more aggressive and malignant. In the 1950s, Foulds first described the stepwise progression of cancer cells through successive stages.
Colon cancer is one of the best-documented examples of tumor progression. Early mutation in the APC gene in colon cells causes a small growth on the colon wall called a polyp. With time, this polyp grows into a benign, pre-cancerous tumor. Further...

Renewal of Skin Epidermal Stem Cells

Renewal of Skin Epidermal Stem Cells

The skin is divided into epidermis, dermis, and hypodermis, the skin's outermost, middle, and inner layers. The human epidermal layer regularly undergoes renewal, where old, dead cells are replaced by new cells. Epidermal stem cells or EpiSCs divide and differentiate to restore the lost cells. For the renewal process, some EpiSCs continuously self-renew. In contrast, few others differentiate into transit-amplifying cells, which later form prickle or spinous cells, followed by granular...

Clinical Applications of Epidermal Stem Cells

Clinical Applications of Epidermal Stem Cells

Epidermal stem cells (EpiSCs) are mainly located at the basal layer of the epidermis. These cells repair minor injuries of the skin and replace dead skin cells. However, EpiSCs’ cannot heal severe wounds such as major burns or those from diabetes or hereditary disorders. In such cases, culturing the epidermal stem cells from the patient is possible and has yielded successful treatment options, such as laboratory-grown skin grafts. These grafts are synthesized using a patient’s own...

Cancer Stem Cells and Tumor Maintenance

Cancer Stem Cells and Tumor Maintenance

Early diagnosis and treatment can often cure cancer. However, even with treatment, residual cells called cancer stem cells (CSC) might remain, often causing tumor recurrence. These cancer stem cells possess the potential for self-renewal and multi-lineage differentiation and are often responsible for the therapeutic resistance displayed in most cancers.
Cancer stem cells are thought to originate from tissue-specific normal stem cells or progenitor cells. The normal stem cells usually reside in...

Combination Therapies and Personalized Medicine

Combination Therapies and Personalized Medicine

Combining two or more treatment methods increases the life span of cancer patients while reducing damage to vital organs or tissue from the overuse of a single treatment. Combination therapy also targets different cancer-inducing pathways, thus reducing the chances of developing resistance to treatment.
The combination of the drug acetazolamide and sulforaphane is a good example of combination therapy to treat cancer. The cells in the interior of a large tumor often die due to the hypoxic and...