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Updated: Feb 19, 2026

Microwave-Assisted Preparation of 1-Aryl-1H-pyrazole-5-amines
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強力で選択的なピロロピリミジン PDE11A4 阻害剤で,薬剤の性能が向上しています

Shams Ul Mahmood1, Rama Krishna Boddu1, Jeremy Eberhard2

  • 1Department of Chemistry and Biochemistry, Sokol Institute of Pharmaceutical Life Sciences, Montclair State University, Montclair, New Jersey 07043, United States.

ACS medicinal chemistry letters
|February 18, 2026
PubMed
まとめ

研究者は,ピロロピリミジン化合物を最適化して,強力なフォスフォディエステラゼ11A4 (PDE11A4) 阻害剤を作成しました. この新しい阻害剤は,改善された医薬品特性と将来の研究のための有望な細胞ベースの活性を示しています.

キーワード:
LLPSの活動は,LLPSの活動である.PDE11A4は,PDE11A4と一致している.細胞ベースの活動である.薬剤学的特性を有する.フォスフォディエステラーゼ阻害剤である.

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