関連する実験動画
Updated: Feb 19, 2026

08:56
Estrogen-Like Effect of Bazi Bushen Capsule in Ovariectomized Rats
Published on: April 7, 2023
1.3K
GGは,腸骨軸の調節を通じて,機械的な卸荷によって誘発された骨の損失を軽減します
Xuezhi Qin1,2, Yu-E Lian2, Hanqin Tang3
1Department of Gastroenterology, The 940th Hospital of Joint Logistics Support Force of Chinese PLA, Lanzhou, China.
Frontiers in nutrition
|February 18, 2026
まとめ
機械的な解荷は骨の損失を引き起こします. プロバイオティクスのラクトバチルス・ラムノサス (LGG) は,腸内微生物群を調節し,腸内バリア機能を改善し,免疫細胞を調節することで,潜在的治療戦略を提供することで,これに対して保護することがあります.
科学分野:
- 微生物学 微生物学とは
- 骨の生物学 骨の生物学
- 免疫学 免疫学とは
背景:
- 宇宙飛行やベッドレストなどの機械的な解荷は,骨の損失を大きくする.
- 腸骨軸は,骨の恒常性にとって極めて重要ですが,解荷中の役割はよく理解されていません.
研究 の 目的:
- 卸載による骨の喪失のメカニズムを調査する.
- 腸-骨軸におけるLactobacillus rhamnosus GG (LGG) の保護の可能性を評価する.
主な方法:
- 後肢卸荷 (HU) マウスモデルを使用しました.
- 腸内微生物群,短鎖脂肪酸 (SCFA),腸内バリアタンパク質,炎症性サイトカイン,調節性T (Treg) 細胞,骨マーカー,およびマイクロアーキテクチャを分析した.
主要な成果:
- HUは腸内微生物群を乱し,SCFAを減少させ,腸内バリア機能を低下させ,炎症を増加させた.
- HUはTreg細胞を減少させ,骨の再編成マーカーを破壊した.
- LGG治療は,腸内微生物群とSCFAを部分的に回復させ,腸内バリアを改善し,炎症を軽減し,骨の損失を軽減しました.
結論:
- LGGは,腸内微生物群の調節,SCFAの変化,腸内バリアの改善,Tレグ細胞の調節を通じて,卸荷誘発性骨減少から保護する可能性があります.
- 腸骨軸をターゲットにすることは,微重力または固定状態での骨の喪失のための治療戦略です.
関連する概念動画
Bone Remodeling
40.6K
Bone remodeling is a continuous and balanced process of bone resorption by osteoclasts and bone formation by osteoblasts. In adults, it helps maintain bone mass and calcium homeostasis. While mechanical stress can stimulate turnover as part of the normal maintenance and reparative process, several hormones also regulate bone remodeling.
40.6K
Osteoclasts in Bone Remodeling
4.3K
Osteoclasts are cells responsible for bone resorption and remodeling. They originate from hematopoietic progenitor cells present in the bone marrow. Numerous progenitor cells fuse to form multinucleated cells, each with 10-20 nuclei. A single osteoclast has a diameter of 150 to 200 µM. These cells have ruffled borders that break down the underlying bone tissue and release minerals such as calcium into the blood in bone resorption. Osteoclasts cling to bones with their ruffled edges during...
4.3K
Role of Vitamins in Maintaining Bone Health
5.7K
The growth and maintenance of bone are regulated by a combination of nutritional factors, including vitamins, such as vitamin A, B12, C, D, and K.
Vitamin A
Vitamin A is involved in the process of bone remodeling. Retinoic acid, the active metabolite of Vitamin A, has nuclear receptors in osteoblasts and osteoclasts, which are involved in bone remodeling.
Vitamin B12
Vitamin B12 acts as a cofactor during the formation of osteoblast-related proteins, such as osteocalcin. Vitamin B12 plays a role...
Vitamin A
Vitamin A is involved in the process of bone remodeling. Retinoic acid, the active metabolite of Vitamin A, has nuclear receptors in osteoblasts and osteoclasts, which are involved in bone remodeling.
Vitamin B12
Vitamin B12 acts as a cofactor during the formation of osteoblast-related proteins, such as osteocalcin. Vitamin B12 plays a role...
5.7K
Bone Disorders
5.6K
Aging and its effect on bone remodeling is the most common cause of bone disorders. In young and healthy people, bone deposition and resorption happen at an equal rate to maintain optimal bone health.
Bone deposition is also affected by the levels of sex hormones like estrogen and testosterone that promote osteoblast activity and bone matrix synthesis. When the level of these hormones decreases due to aging, it causes a reduction in bone deposition. As a result, bone resorption by osteoclasts...
Bone deposition is also affected by the levels of sex hormones like estrogen and testosterone that promote osteoblast activity and bone matrix synthesis. When the level of these hormones decreases due to aging, it causes a reduction in bone deposition. As a result, bone resorption by osteoclasts...
5.6K
Hormones and Bone Tissue
3.9K
The endocrine system produces and secretes hormones, which interact with the skeletal system. These hormones control bone growth, maintain bone once it is formed, and remodel it.
Hormones That Influence Osteoblasts and/or Maintain the Matrix
Several hormones are necessary for controlling bone growth and maintaining the bone matrix. The pituitary gland secretes growth hormone (GH), which, as its name implies, controls bone growth. This happens in several ways: first, it triggers chondrocyte...
Hormones That Influence Osteoblasts and/or Maintain the Matrix
Several hormones are necessary for controlling bone growth and maintaining the bone matrix. The pituitary gland secretes growth hormone (GH), which, as its name implies, controls bone growth. This happens in several ways: first, it triggers chondrocyte...
3.9K
