代謝機能障害に関連するステアトス性肝疾患に対する抵抗トレーニング:体系的なレビューとメタ解析
Yun Chen1, Xiaoya Qiao1, Xinyi Zou1
1Department of Sport and Health Sciences, Nanjing Sport Institute, Nanjing, China.
Frontiers in physiology
|February 18, 2026
まとめ
抵抗運動は,ALTレベルを下げ,肝臓の脂肪を減らすことで,代謝機能障害に関連したステアトス性肝疾患 (MASLD) の患者の肝臓の健康を大幅に改善します. この安全な介入は,エアロビック運動を行うことができない人のための代替案を提供します.
科学分野:
- 肝臓病理学 肝臓病理学
- 運動生理学 運動生理学
- メタボリック疾患
背景:
- メタボリック機能障害に関連したステアトス肝疾患 (MASLD),以前はNAFLDは,世界的な健康上の懸念が高まっています.
- MASLDの効果的な管理戦略は,運動などのライフスタイル介入が有望であることを示し,非常に重要です.
- 異なる運動モードの特定の影響を理解することは,臨床指導に不可欠です.
研究 の 目的:
- MASLD患者の主要な指標に対する抵抗運動の効果を体系的に評価する.
- レジスタンストレーニングが肝臓酵素を改善し,肝臓ステアトーシスを軽減する効果を判断する.
- MASLD管理のための最適な抵抗運動パラメータを確立する.
主な方法:
- ランダム化対照試験 (RCT) の包括的なメタ解析が行われました.
- 主要なデータベース (PubMed,Embaseなど) で検索を行いました. 2025年3月までです.
- 品質評価はコクランリスク・オブ・バイアス・ツールを使用し,メタ解析はRevMan 5.3.3を用いて行われた.
主要な成果:
- 395人の参加者を含む11件のRCTを分析した.
- アラニンアミノトランスフェラーゼ (ALT) 濃度の大幅な低下が観察されました (MD = -4.44 U/L).
- 画像検査の8件のうち7件で,肝臓の脂肪含有量の大幅な減少が報告され,重大な有害事象は報告されなかった.
結論:
- 抵抗運動は,MASLD患者のALTレベルと肝硬化症を改善するための効果的な介入です.
- 推奨用量:全身,多筋トレーニング,8〜10回の運動,60〜80%の1RM,≥3回/週,≥12週間.
- この手法は安全で有益であり,特にALT値が上昇した患者やエアロビック運動に対する不耐性を持つ患者には安全であり,有益であるが,より大きな研究が必要である.
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