関連する実験動画

Updated: Feb 19, 2026

Author Spotlight: Evaluating the Impact of Immediate Partial Removal of Cumulus-Oocyte Complexes on Fertilization Efficiency and Embryo Quality

Author Spotlight: Evaluating the Impact of Immediate Partial Removal of Cumulus-Oocyte Complexes on Fertilization Efficiency and Embryo Quality

Published on: October 18, 2024

IVF/ICSIを受けた原因不明の不妊症のカップルの累積生児に影響を与えるリスク要因の分析

Ran Liu^{1,2,3,4,5,6,7}, Tong Wu^{1,2,3,4,5,6,7,8}, Guoyu Ding^{1,2,3,4,5,6,7}

¹State Key Laboratory of Reproductive Medicine and Offspring Health, Center for Reproductive Medicine, Institute of Women, Children and Reproductive Health Shandong University Jinan Shandong People's Republic of China.

Reproductive medicine and biology

|February 18, 2026

まとめ

原因不明の不妊症 (UI) の危険因子には,女性の高齢化,BMIの上昇,アンチミュレリアンホルモン (AMH) の低下が含まれる. これらの要因を特定することで,体外受精/細胞内精子注射 (IVF/ICSI) を受けているカップルのアウトカムが改善されます.

科学分野:

生殖医学は,生殖器医学である.
不妊症に関する研究
助産生殖技術 (APT) とは,助産生殖技術 (APT) とは,助産生殖技術 (APT) とは,助産生殖技術 (APT) とは.

背景:

原因不明の不妊症 (UI) は,不妊カップルの有意な部分に影響します.
特定の危険因子を特定することは,治療結果の改善に不可欠です.
試験管内受精/細胞内プラズマ精子注射 (IVF/ICSI) などの助産生殖技術は一般的に使用されています.

研究の目的:

最初のIVF/ICSIサイクルのカップルにおける原因不明の不妊症 (UI) に関連する特定のリスク要因を特定する.
これらの要因が生育率に与える影響を分析する.

主な方法:

最初のIVF/ICSIサイクルを体験した不妊カップル5465人を対象とした遡及コホート研究.
活産の予測要因を特定するための多変数ロジスティック回帰分析.
分析は,人口,ホルモン,および身体的特徴に焦点を当てました.

主要な成果:

UI患者における生産の主要なネガティブな予測要因には,女性年齢 ≥35歳,男性年齢,女性BMI ≥27.5 kg/m2,低抗ムレリアンホルモン (AMH <1.2 ng/mL),中程度の子宮内膜の厚さ (0.7-1.0 cm) が含まれていた.
採取された卵子細胞の数がより多いことは,累積生児 (CLB) と正に相関していました.
1回の完全なIVF/ICSIサイクル後の累積生児率は62.2%でした.

結論:

女性の年齢と卵巣リザーブ指標は,UI患者における卵細胞の産量,胚の発達,および生産の結果に影響を与える主要な要因です.
これらの危険因子を理解することで,不妊治療の最適化に役立ちます.
研究対象集団におけるUIの罹患率は8.8%であった.

キーワード:

IVF/ICSIによる受精を推奨しています.累積的な生児出生量リスクファクターリスクファクターリスクファクター原因不明の不妊症による不妊症

さらに関連する動画

OP-IVM: Combining In vitro Maturation after Oocyte Retrieval with Gynecological Surgery

OP-IVM: Combining In vitro Maturation after Oocyte Retrieval with Gynecological Surgery

Published on: May 9, 2021

Author Spotlight: Multiplex Immunohistochemistry for Understanding Immune Regulation by Uterine NK Cells in Pregnancy

Author Spotlight: Multiplex Immunohistochemistry for Understanding Immune Regulation by Uterine NK Cells in Pregnancy

Published on: October 25, 2024

関連する概念動画

In Vitro Fertilization

In Vitro Fertilization

In vitro fertilization (IVF) is a form of assisted reproductive technology where an egg is fertilized with sperm in a controlled laboratory environment before transferring the resulting embryo into the uterus. This process is designed to help individuals and couples experiencing difficulties conceiving.
The IVF process begins with ovarian stimulation, during which reproductive endocrinologists prescribe hormonal medications to stimulate the ovaries to produce multiple eggs instead of the single...

Infertility in Females

Infertility in Females

Female infertility is defined as the inability to conceive after a year of regular, unprotected intercourse and affects about 10–15% of couples worldwide. The primary cause of female infertility is ovulatory disorders, which hinder the release of eggs. These disorders can be classified as hypothalamic amenorrhea, polycystic ovarian syndrome (PCOS), premature ovarian failure, and hyperprolactinemic anovulation disorders.
Endometriosis, a condition characterized by abnormal growth of...

Infertility in Males

Infertility in Males

Male infertility affects millions of couples worldwide, arising from various factors that impact different stages of the reproductive process. An endocrine imbalance resulting from conditions like hypogonadism, Klinefelter syndrome, or pituitary disorders can disrupt hormone levels and reduce sperm production. Testicular defects, such as tumors, cryptorchidism, atrophic testes, abnormal sperm morphology, and low sperm count or motility, may arise due to genetic factors, structural...

Factors Affecting the Risk of Infection

Factors Affecting the Risk of Infection

The hosts' susceptibility to infection depends on several factors. The integrity of the skin and mucous membranes helps protect the body against microbial attacks. When the skin is altered, the chance of infection, limb loss, and even death increases.
The integrity and count of the white blood cells help the body resist pathogens and fight infection. When impaired, it reduces the body's resistance to pathogens. The acidic pH levels of the gastrointestinal, genitourinary tracts, and skin...

Types of Biopharmaceutical Studies: Controlled and Non-Controlled Approaches

Types of Biopharmaceutical Studies: Controlled and Non-Controlled Approaches

Biopharmaceutical studies constitute a vital field aiming to enhance drug delivery methods and refine therapeutic approaches, drawing upon diverse interdisciplinary knowledge. In research methodologies, the choice between controlled and non-controlled studies significantly influences the study's reliability and accuracy.
Non-controlled studies, commonly employed for initial exploration, lack a control group, rendering them susceptible to biases and external influences. In contrast,...

Birth Control Methods

Birth Control Methods

Vasectomy is a surgical form of male sterilization that involves severing and sealing the vasa deferentia, preventing sperm from mixing with semen during ejaculation. Because a vasectomy does not impact the testes' ability to produce testosterone, hormone levels, libido, and sexual function generally remain unchanged. While vasectomy is highly effective in preventing pregnancy, with a success rate near 99.85%, rare cases of recanalization (spontaneous reconnection) can occur. Although...