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Updated: Feb 19, 2026

Suppression of Pro-fibrotic Signaling Potentiates Factor-mediated Reprogramming of Mouse Embryonic Fibroblasts into Induced Cardiomyocytes
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Suppression of Pro-fibrotic Signaling Potentiates Factor-mediated Reprogramming of Mouse Embryonic Fibroblasts into Induced Cardiomyocytes

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USP10 MIにおけるcGAS-STINGシグナリングを抑制するためにMTX2をデウビキチン化します

Guo-Jun Zhao1, Hui-Ting Shi1, Xiaoxu Tian1

  • 1Department of Cardiology (G.-J.Z., H.-T.S., X.T., L.K., H.L., G.L., H.T., Y.Z.), The First Affiliated Hospital of Zhengzhou University, China.

Circulation research
|February 18, 2026
PubMed
まとめ

USP10 (ユビキチン特異ペプチダゼ10) は,cGAS-STING経路を阻害することによって,心筋梗塞 (MI) の後の心臓損傷から保護します. 国境地帯の心筋細胞におけるUSP10レベルを回復することは,潜在的にMIの治療戦略を提供します.

キーワード:
細胞死亡 細胞死心不全は,心不全を意味する.低酸素症 低酸素症 低酸素症ミュタゲネシスの変異.タンパク質の安定性

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