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Updated: Feb 20, 2026

Induction of Ocular Surface Inflammation and Collection of Involved Tissues
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細胞内C5a-mtC5aR1軸は,DRP1-媒介型ミトコンドリア機能不全により,乾燥眼におけるネクロプトシスを促進する

Limei Wang1,2, Haijing Yan1,3, Yetao Shen1,2

  • 1Eye Hospital and School of Ophthalmology and Optometry, Wenzhou Medical University, Zhejiang, China.

Investigative ophthalmology & visual science
|February 18, 2026
PubMed
まとめ

この研究は,C5a-ミトコンドリアのC5a受容体1 (mtC5aR1) 経路が,乾燥眼 (DE) の角膜細胞損傷を誘導することを明らかにしています. JPE-1375でmtC5aR1を阻害すると,マウスモデルで炎症を軽減し,DEから保護します.

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