関連する実験動画

Updated: Feb 20, 2026

Reconstitution of Basic Mitotic Spindles in Spherical Emulsion Droplets
10:52

Reconstitution of Basic Mitotic Spindles in Spherical Emulsion Droplets

Published on: August 13, 2016

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DYN-1は,SPD-2とPLK-1の局所化とミトーシス・スピンドル・ポール組織を調節する

Carter Dierlam1, Stephanie Held2, Jiya Hastings2

  • 1Department of Cell Biology and Molecular Genetics, University of Maryland College Park, College Park, MD 20742.

Molecular biology of the cell
|February 18, 2026
PubMed
まとめ

ダイナミンの同類であるDYN-1は,C. elegans. のスパインドル組成と重要なミトーシスタンパク質の局所化を調節する. この研究は,DYN-1を明らかにしています.

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Live Cell Imaging to Assess the Dynamics of Metaphase Timing and Cell Fate Following Mitotic Spindle Perturbations07:14

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Spindle Assembly02:50

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The bipolar configuration of the mitotic spindle facilitates chromosomal segregation, preparing the cell for division. One mechanism that ensures...
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The Spindle Assembly Checkpoint

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As cells progress into mitosis, the nuclear envelope breaks down, and the condensed chromosomes are exposed to the array of bipolar microtubules of the mitotic spindle. The kinetochore, a large, disc-shaped protein complex, is present at the centromere region of the sister chromatids and acts as a binding site for the microtubules.  Usually, the plus-end of a single microtubule is embedded within the kinetochore. However, some kinetochores first establish lateral contact with the side-wall...
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Microtubules form through the end-to-end polymerization of tubulin heterodimers. Kinetochore microtubules originate from the spindle poles, and their plus-ends connect with the kinetochores on sister-chromatids. Ndc80 protein complexes, present on the kinetochore, form low-affinity links with the plus end of these kinetochore microtubules.
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