プロバイオティック発酵グアバ (Psidium guajava L.) のジュースにおける生物活性物質の特徴と,その抗高血糖活性に対する体系的な評価
Yazhou Xu1, Tao Xiong2, Xinyi Kang1
1School of Food Science and Technology, Nanchang University, No. 235 Nanjing East Road, Nanchang, 330047, Jiangxi, PR China.
Plant foods for human nutrition (Dordrecht, Netherlands)
|February 18, 2026
まとめ
プロバイオティックで発酵したグアバジュース (FM) は,高血糖症に関連した酵素を効果的に抑制し,インスリン抵抗性細胞のグルコース吸収を改善します. この機能的な食品は,血糖値を自然に管理する有望な効果を示しています.
科学分野:
- 機能的な食品に関する研究
- メタボロミクスとは
- ニュートラセウティカル開発
背景:
- 副作用を最小限に抑える天然の抗高血糖剤の開発は極めて重要です.
- Lacticaseibacillus paracasei NCUH012072 (FM) で発酵したグアバジュースには,抗糖尿病効果が研究されました.
研究 の 目的:
- FM.における抗糖尿病的可能性と生物活性物質を包括的に調査する.
- インビトロアッセイ,メタボロミクス,バイオインフォマティック検証を用いて,抗高血糖活性を評価する.
主な方法:
- インビトロバイオアッセイ (酵素阻害,抗酸化能力,インスリン抵抗性細胞モデル).
- 非ターゲティングの代謝学と生物情報分析.
- 液体染色体-質量スペクトロメトリー (AF-LC-MS) と組み合わせたアフィニティ超濾過.
主要な成果:
- FMは炭水化物を代謝する酵素 (α-アミラーゼ,α-グルコシダゼ) とPTP1Bを著しく抑制した.
- FMは抗酸化能力を高め,インスリン抵抗性HepG2細胞のグルコース吸収を向上させた.
- フラボノイド,フェノール酸,および (R) -リポ酸を含む主要な抗高血糖代謝物質が特定されました.
結論:
- プロバイオティックで発酵したグアバジュースは,重要な抗高血糖特性を発揮します.
- この研究は,発酵食品中の生物活性化合物を特定するための戦略を提供します.
- 発見は,高血糖管理のための発酵された果物ベースの機能食品の開発をサポートしています.
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