関連する実験動画

Updated: Feb 20, 2026

Screening Traditional Chinese Medicine Compounds for Inhibiting UCHL3 Activity Based on Molecular Docking and Deubiquitinating Enzyme Probe Technology
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Screening Traditional Chinese Medicine Compounds for Inhibiting UCHL3 Activity Based on Molecular Docking and Deubiquitinating Enzyme Probe Technology

Published on: November 22, 2024

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Ube2R1の活性が,そのN端の近くに結合するナノボディによって調節される

Charlotte Wijne1,2, Pavana Suresh1, Richard Dela Rosa1

  • 1Program in Cellular and Molecular Medicine, Boston Children's Hospital, Boston, Massachusetts, U.S.A.

The Biochemical journal
|February 18, 2026
PubMed
まとめ

研究者らは,Ube2R1酵素のN端を標的としたナノボディ (VHH12R1) を開発した. このナノボディはUbe2R1の自己ポリユビキチン化を選択的に阻害し,ユビキチン結合酵素の新たな調節機構を明らかにしている.

キーワード:
酵素調節による酵素調節です.ナノボディは,ナノボディです.Ube2R1は,Ube2R1という名前で使われています.ユービキチン結合酵素 (E2)ユビキチネーション (Ubiquitination) とは ユビキチネーション (Ubiquitination) とは ユビキチネーション (Ubiquitination) とは

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