関連する実験動画

Updated: Feb 20, 2026

A Standard Methodology to Examine On-site Mutagenicity As a Function of Point Mutation Repair Catalyzed by CRISPR/Cas9 and SsODN in Human Cells
10:07

A Standard Methodology to Examine On-site Mutagenicity As a Function of Point Mutation Repair Catalyzed by CRISPR/Cas9 and SsODN in Human Cells

Published on: August 25, 2017

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CRISPR-Cas9遺伝子駆動要素によって課される変異負荷の上限

Michael S Overton1, Sean E Guy1, Xingsen Chen1

  • 1Department of Ecology, Behavior and Evolution, University of California San Diego, La Jolla, CA 92093, United States.

G3 (Bethesda, Md.)
|February 18, 2026
PubMed
まとめ

CRISPR-Cas9遺伝子駆動 (CCGD) は,酵母における変異率やヘテロジゴシティの喪失に検出可能な影響を示さなかった. これらの発見は,CCGDが許容可能な進化的リスクをもたらす可能性を示唆し,他のシステムでのさらなる研究を正当化しています.

キーワード:
遺伝子ドライブは遺伝子ドライブです.ヘテロジゴシティの喪失変異 変異 変異 変異 変異オフターゲットの効果

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