関連する実験動画

Updated: Jul 30, 2026

Kinetic Screening of Nuclease Activity using Nucleic Acid Probes
06:52

Kinetic Screening of Nuclease Activity using Nucleic Acid Probes

Published on: November 1, 2019

8.8K

純粋なDNAでコードされたペプチドライブラリを介して強化されたスクリーニングは,Fmoc修正によって有効にされます

Qiujin He1,2, Yanhui Wang1, Xiyuan Tang3

  • 1Biotech Drug Research Center, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China.

Proceedings of the National Academy of Sciences of the United States of America
|February 18, 2026
PubMed
まとめ

研究者は,DNAでコードされたペプチドライブラリ (PDEL) のための新しい浄化方法を開発し,より長く,より高い純度のペプチド治療法の作成を可能にしました. この画期的な発見は,ライブラリ合成における以前の限界を克服することによって,ペプチドベースの薬剤発見を前進させます.

キーワード:
DNAで暗号化された図書館です.DNAでコードされたペプチドライブラリアミノプロテクション アミノプロテクション細胞に浸透するペプチド.ペプチドスクリーニング

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Proofreading01:43

Proofreading

Synthesis of new DNA molecules starts when DNA polymerase links nucleotides together in a sequence that is complementary to the template DNA strand. DNA polymerase has a higher affinity for the correct base to ensure fidelity in DNA replication. The DNA polymerase furthermore proofreads during replication, using an exonuclease domain that cuts off incorrect nucleotides from the nascent DNA strand.Errors during Replication Are Corrected by the DNA Polymerase EnzymeGenomic DNA is synthesized in...
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Mismatch Repair

Overview
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Covalently Linked Protein Regulators

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Genome Copying Errors02:46

Genome Copying Errors

DNA replication is a well-evolved process that copies millions of base pairs with high fidelity during each cell division. Occasionally a wrong base or a long stretch of wrong bases may get added to the daughter strands. If the errors are left unchecked, cells might accumulate several mutations that might endanger their  survival. Therefore, the copying errors are checked and repaired at three levels.
Proofreading01:31

Proofreading

Synthesis of new DNA molecules is carried out by the enzyme DNA polymerase, which adds nucleotides on the daughter strand complementary to the template DNA strand. DNA polymerase has a higher affinity to add the correct base and ensures fidelity during DNA replication. Furthermore,  it exhibits proofreading activity during replication, using an exonuclease domain that cuts off incorrect nucleotides from the nascent DNA strand.
Errors During Replication are Corrected by the DNA Polymerase Enzyme