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Updated: Feb 20, 2026

Pharmacophore Modeling for Targets with Extensive Ligand Libraries: A Case Study on SARS-CoV-2 Mpro
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カリプラジンを二重障害に対して,二次性薬剤ホルモンの最適化を介して調整する

Caleb D Vogt1, Julie Sanchez2, Alessandro Bonifazi3

  • 1Medicinal Chemistry Section, Molecular Targets and Medications Discovery Branch, National Institute on Drug Abuse - Intramural Research Program, National Institutes of Health, 333 Cassell Drive, Baltimore, MD, 21224, United States.

European journal of medicinal chemistry
|February 18, 2026
PubMed
まとめ

新しい薬剤候補は,併発性精神疾患と精神刺激剤使用障害の治療に有望である. これらの新しい化合物は,ドーパミンD3受容体の選択性を向上させ,カリプラジンと比較して副作用を潜在的に軽減します.

キーワード:
双極性障害の双極性障害とはビトピックリガンドカリプラジン (Cariprazine) とはコカイン・コカインドーパミンD ((2) レセプタードーパミンD ((3) レセプター二重障害による二重障害である.メジャー・デプレッション・メジャー・デプレッションメタンフェタミンは,メタンフェタミンの精神刺激剤使用障害 精神刺激剤使用障害統合失調症 統合失調症 統合失調症薬物乱用症候群とは,薬物乱用症候群である.

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