ラマダンの断食と成人における発作の活動: 体系的なレビューとメタ解析
Ismail A Ibrahim1, Sally Shaaban2, Mandy Elewa3
1Faculty of Health Sciences, Fenerbahçe University, İstanbul, Turkey; Global Alliance of Young Researchers, Istanbul, Turkey; YES EM-AO: Inter-Regional Research Collaborative Team, Young Epilepsy Section (YES), International League Against Epilepsy, for the Eastern Mediterranean and Asian & Oceanian Regions.
Epilepsy & behavior : E&B
|February 18, 2026
まとめ
ラマダンの断食は,一部の患者にとって安全である可能性があり,残りの60%以上が発作のない状態です. しかし,ポリセラピーや中断されたリズムなどの要因は,発作のリスクを高め,安全な断食慣行のための医学的監督を必要とします.
科学分野:
- 神経学 神経学とは
- クリニカル・メディシン 臨床医学
- 公共衛生は公衆衛生である.
背景:
- ラマダンの断食は,夜明けから夕暮れまで,食べ物や液体を摂取しないことを意味します.
- 断続的な断食とケトジェニックダイエットは,発作制御を改善する可能性があることを示しています.
- ラマダンの断食がに与える影響を理解することは,患者の管理に不可欠です.
研究 の 目的:
- 断続的なラマダンの断食と,成人におけるの発作活動の関連性を分析する.
- 発作制御に対する断食の効果に関する既存の証拠を基に構築する.
主な方法:
- 2000年から2025年までの主要データベース (PubMed,Scopus,Web of Science,Cochrane Library,Embase) の間で体系的な文献検索を行いました.
- 含める基準は,ラマダンの断食と/発作に焦点を当てた.
- 発作の頻度と状態を評価するためにランダム効果モデルを用いたメタ分析.
主要な成果:
- 患者の61.1%がラマダーン中に発作のない状態であったが,有意な異質性 (I2 = 87.7%) があった.
- ポリセラピーを受けている患者で発作のリスクが高く,ベースラインでのコントロールが悪く,断食期間が長く,または高カリウム濃度が観察されました.
- 発作のない期間が長くなり,ラマダンの前の睡眠時間が長くなると,安全な断食が予測され,発作のない1週間と1時間の睡眠が改善された.
結論:
- エピレプシー患者の有意な割合は,ラマダーン中に発作のない状態にすることができます.
- 高い研究変動性は,標準化された研究プロトコルの必要性を強調しています.
- 選択されたエピレプシー患者は,適切な医療監督の下でラマダンの断食を安全に実践することができます.
関連する概念動画
01:24Epilepsy and Seizures: Overview
1.4K
Epilepsy is a chronic neurological disease marked by recurrent, unpredictable seizures. These seizures are caused by abnormal electrical discharges in the brain, leading to behavior, sensation, or consciousness alterations. They can also cause transient impairment of awareness, interfering with daily activities.
Various factors can trigger epilepsy, including genetic factors, brain damage, metabolic causes, and unknown etiology. Diagnosis of epilepsy involves electroencephalography (EEG), which...
Various factors can trigger epilepsy, including genetic factors, brain damage, metabolic causes, and unknown etiology. Diagnosis of epilepsy involves electroencephalography (EEG), which...
1.4K
01:20Antiepileptic Drugs: Potassium Channel Activators
732
Ezocgabine or retigabine, an antiepileptic drug of remarkable efficacy, has revolutionized the management of seizures. It is a potassium channel activator, explicitly targeting the family of Q subtype potassium channels. It enhances the transmembrane potassium currents, regulating neuronal excitability. This action stabilizes the resting membrane potential, a pivotal factor in mitigating the hyperexcitability that characterizes epilepsy.
Ezogabine has gained approval as an adjunctive treatment...
Ezogabine has gained approval as an adjunctive treatment...
732
01:20Antiepileptic Drugs: Modulators of Neurotransmitter Release Mediated by SV2A Protein
968
Antiepileptic drugs, such as levetiracetam (Keppra) and brivaracetam (Briviact), have emerged as crucial tools in managing epilepsy. These medications exert their therapeutic effects by targeting the synaptic vesicle protein SV2A, a transmembrane glycoprotein primarily found in the brain.
SV2A is a transmembrane glycoprotein located predominantly in the brain, modulating the release of neurotransmitters for neuronal communication. Both levetiracetam and brivaracetam exhibit a high affinity for...
SV2A is a transmembrane glycoprotein located predominantly in the brain, modulating the release of neurotransmitters for neuronal communication. Both levetiracetam and brivaracetam exhibit a high affinity for...
968
01:13Seizures: Classification
1.8K
Epilepsy is primarily characterized by unpredictable seizures, either provoked by an identifiable factor, such as injury or illness, or unprovoked, occurring spontaneously without apparent cause.
Seizures are typically classified into two main categories: focal and generalized seizures.
Focal Seizures
Focal seizures originate from specific regions of the brain. These seizures are further sub-classified into two types:
Seizures are typically classified into two main categories: focal and generalized seizures.
Focal Seizures
Focal seizures originate from specific regions of the brain. These seizures are further sub-classified into two types:
1.8K
01:08Antiepileptic Drugs: Sodium Channel Blockers
1.9K
Antiepileptic drugs are specialized medications that prevent seizures in individuals diagnosed with epilepsy. These drugs primarily function by blocking the movement of sodium ions through channels in the neuronal membrane, inhibiting the repetitive firing of action potentials often associated with seizures.
Sodium channel blockers modulate ion channels, particularly voltage-gated sodium channels. They block only sodium ion movement.
Among the most commonly prescribed antiepileptic drugs are...
Sodium channel blockers modulate ion channels, particularly voltage-gated sodium channels. They block only sodium ion movement.
Among the most commonly prescribed antiepileptic drugs are...
1.9K
01:14Antiepileptic Drugs: Glutamate Antagonists
1.0K
Glutamate is a fundamental neurotransmitter in the central nervous system, playing a vital role in neuronal communication and various cognitive processes. Glutamate stands as the principal excitatory neurotransmitter in the brain. Its presence is crucial for the communication between neurons, underpinning essential processes such as synaptic transmission, neuronal excitability, and plasticity. These functions are vital for higher-order cognitive processes, including learning and memory. The...
1.0K