Jove
Visualize
お問い合わせ
JoVE
x logofacebook logolinkedin logoyoutube logo
JoVEについて
概要リーダーシップブログJoVEヘルプセンター
著者向け
出版プロセス編集委員会範囲と方針査読よくある質問投稿
図書館員向け
推薦の声購読アクセスリソース図書館諮問委員会よくある質問
研究
JoVE JournalMethods CollectionsJoVE Encyclopedia of Experimentsアーカイブ
教育
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab Manual教員リソースセンター教員サイト
利用規約
プライバシーポリシー
ポリシー

関連する概念動画

Toxicity Testing in Animals01:23

Toxicity Testing in Animals

25
Toxicity tests in animals are grounded on two main assumptions: first, the effects observed in laboratory animals can be extrapolated to humans, especially when adjusted for body surface area; second, high-dose exposure in animals is essential to identify potential human hazards from lower doses. This is based on the quantal dose-response concept, which faces the challenge of extrapolating results from relatively few test animals to much larger human populations. For example, a 0.01% incidence...
25
Toxicokinetics: Overview01:21

Toxicokinetics: Overview

35
Studies that assess how a drug is absorbed, distributed, metabolized, and excreted (ADME) at toxic doses are termed toxicokinetics. Understanding toxicokinetics helps predict adverse drug reactions (ADRs) and manage toxicity in humans.Toxicokinetics differs from pharmacokinetics mainly in the dose levels studied, with toxicokinetics focusing on higher toxic doses. The kinetics at these levels can be non-linear due to altered physiological processes. Toxicodynamics examines the relationship...
35
Drug Regulation01:25

Drug Regulation

3.1K
Drug regulation encompasses the management of drug usage by evaluating its safety and efficacy through assessments conducted by regulatory authorities. Regrettably, the history of drug regulation is marred by several catastrophic events. One such incident is the Elixir Sulfanilamide tragedy, in which the toxic compound diethyl glycol was included in a sweet-tasting medication, leading to numerous fatalities. This event prompted the enactment of the Food, Drug, and Cosmetic Act in 1938. Under...
3.1K
Preclinical Development: Overview01:28

Preclinical Development: Overview

6.1K
Preclinical development consists of a series of tests that ensure the safety and efficacy of a new therapeutic compound before it is tested in humans. There are four main phases to this process. First, safety pharmacology tests are conducted to ensure the drug does not produce any acutely harmful effects. These tests examine parameters such as bronchoconstriction, cardiac dysrhythmias, blood pressure changes, and ataxia. Next, preliminary toxicological testing is performed to determine the...
6.1K
Impact of Pharmacokinetic–Pharmacodynamic Models: Regulatory Decisions01:15

Impact of Pharmacokinetic–Pharmacodynamic Models: Regulatory Decisions

24
PK–PD modeling has significantly influenced FDA regulatory decisions, particularly drug approval, dosage optimization, and labeling. These models integrate pharmacokinetics (PK) and pharmacodynamics (PD) to predict drug behavior and effects, aiding in optimizing dosing regimens and enhancing the probability of clinical trial success.One notable example is Nesiritide (Natrecor®), a recombinant human brain natriuretic peptide for treating acute decompensated congestive heart failure...
24
Steps in Outbreak Investigation01:18

Steps in Outbreak Investigation

613
In the ever-evolving field of public health, statistical analysis serves as a cornerstone for understanding and managing disease outbreaks. By leveraging various statistical tools, health professionals can predict potential outbreaks, analyze ongoing situations, and devise effective responses to mitigate impact. For that to happen, there are a few possible stages of the analysis:
613

こちらも読む

関連記事

共著者、ジャーナル、引用グラフによってこの研究に関連する記事。

並び替え
Same author

Europe's bottlenecks to the operationalisation of Essential Biodiversity Variables for Environmental Policy Support.

npj biodiversity·2026
Same author

Computational characterisation of ecological hazard and risk of environmental mixtures.

EFSA journal. European Food Safety Authority·2025
Same author

Reporting Chemical Data in the Environmental Sciences.

ACS environmental Au·2025
Same author

The use of diagnostic tools to assess the risks of chemicals to freshwater ecosystems: towards a unified evaluation framework.

Environmental management·2025
Same author

Updating statistical practice in ecotoxicology: reflections and recommendations.

Integrated environmental assessment and management·2025
Same author

Generalized additive modeling as a tool for the analysis of the time course of tail coiling behavior in zebrafish (Danio rerio) embryos - A proof-of-concept study with nicotine, a known developmental neurotoxicant.

Aquatic toxicology (Amsterdam, Netherlands)·2025

関連する実験動画

Updated: Feb 20, 2026

Ecotoxicological Methodologies to Evaluate Biomarkers at Different Scales in Neotropical Anurans
08:14

Ecotoxicological Methodologies to Evaluate Biomarkers at Different Scales in Neotropical Anurans

Published on: April 28, 2023

837

規制エコトキシコロジーの進行中の統計分析:開発,プロセス,意見

Raoul Wolf1, David R Fox2,3, S Jannicke Moe4,5

  • 1Norwegian Geotechnical Institute (NGI), Oslo, 0484 Norway.

Integrated environmental assessment and management
|February 18, 2026
PubMed
まとめ
この要約は機械生成です。

規制エコトキシコロジーは,最新の統計的方法が必要です. この特別シリーズは,統計的ツールやモデルの最近の進歩を調査し,現代のリスク評価の課題に対処し,将来の研究を導く.

キーワード:
濃度-反応モデリング一般化された線形モデルと添加モデル.仮説テスト 仮説テストミックス・エフェクト・モデル規制統計に関する統計です.

さらに関連する動画

Use of a Battery of Chemical and Ecotoxicological Methods for the Assessment of the Efficacy of Wastewater Treatment Processes to Remove Estrogenic Potency
09:49

Use of a Battery of Chemical and Ecotoxicological Methods for the Assessment of the Efficacy of Wastewater Treatment Processes to Remove Estrogenic Potency

Published on: September 11, 2016

14.7K
Demonstration of the Sequence Alignment to Predict Across Species Susceptibility Tool for Rapid Assessment of Protein Conservation
16:02

Demonstration of the Sequence Alignment to Predict Across Species Susceptibility Tool for Rapid Assessment of Protein Conservation

Published on: February 10, 2023

3.3K

関連する実験動画

Last Updated: Feb 20, 2026

Ecotoxicological Methodologies to Evaluate Biomarkers at Different Scales in Neotropical Anurans
08:14

Ecotoxicological Methodologies to Evaluate Biomarkers at Different Scales in Neotropical Anurans

Published on: April 28, 2023

837
Use of a Battery of Chemical and Ecotoxicological Methods for the Assessment of the Efficacy of Wastewater Treatment Processes to Remove Estrogenic Potency
09:49

Use of a Battery of Chemical and Ecotoxicological Methods for the Assessment of the Efficacy of Wastewater Treatment Processes to Remove Estrogenic Potency

Published on: September 11, 2016

14.7K
Demonstration of the Sequence Alignment to Predict Across Species Susceptibility Tool for Rapid Assessment of Protein Conservation
16:02

Demonstration of the Sequence Alignment to Predict Across Species Susceptibility Tool for Rapid Assessment of Protein Conservation

Published on: February 10, 2023

3.3K

科学分野:

  • 生態毒理学 エコトキシコロジ
  • 環境リスク評価 環境リスク評価
  • 統計モデリング 統計モデリング

背景:

  • 生態毒理学における規制上のリスク評価は,統計的方法や計算ツールにおける進歩に遅れをとっている.
  • 生態毒性学者の間では,生態毒性データの統計分析に関する2006年OECDガイドラインの更新に重要な関心があります.
  • 最近のSETACの会合では,生態毒理学の現代的な統計的アプローチの必要性が強調されました.

研究 の 目的:

  • 統計的生態毒理学の現状を調査する.
  • 生態毒理学の統計方法における最近の進展,プロセス,意見について考える.
  • 統計的生態毒理学に専念したIEAMのスペシャルシリーズの概要を提供します.

主な方法:

  • IEAMのスペシャルシリーズが立ち上げられ,様々なセクターからの貢献が求められました.
  • シリーズにはオリジナルの記事,簡潔なコミュニケーション,ワークショップの要約が含まれています.
  • 内容は,濃度反応モデリング,仮説テスト,毒性指標 (ECX,NOEC,BMD),種感受性分布 (SSD) モデリング,およびメカニズム効果モデリングです.

主要な成果:

  • 特別シリーズには,学界,産業,政府からの11件の論文が含まれています.
  • 主なトピックには,濃度-反応関係に関する一般化された線形モデルの進歩が含まれます.
  • このシリーズは,確立された毒性メトリックの有用性と新しいモデリングアプローチの適用を検証しています.

結論:

  • 現代的な統計的手法により,生態学毒性リスク評価を改善する大きな可能性を秘めています.
  • 統計分析の課題に取り組むことは,規制エコトキシコロジーの進歩に不可欠です.
  • この特別シリーズでは,エコ毒性データに近代的な統計技術を適用する際の機会と課題を強調しています.