関連する実験動画

Updated: Feb 20, 2026

Parallel Interrogation of β-Arrestin2 Recruitment for Ligand Screening on a GPCR-Wide Scale using PRESTO-Tango Assay
09:03

Parallel Interrogation of β-Arrestin2 Recruitment for Ligand Screening on a GPCR-Wide Scale using PRESTO-Tango Assay

Published on: March 10, 2020

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オキシトシン受容体のホモダイマーを標的にするバイバルントリガンドは,選択的に異なるGタンパク質とβ-アレスティン経路を活性化します

Marta Busnelli1, Alessandro Gori2, Bice Chini1

  • 1Institute of Neuroscience, National Research Council, Vedano al Lambro (MB), 20854, Italy; NeuroMI Milan Center for Neuroscience, University of Milano-Bicocca, Milan 20126, Italy.

Biochemical pharmacology
|February 18, 2026
PubMed
まとめ

新種の双価オキシトシンアナログ (dOTK) は,オキシトシン受容体 (OTR) ホモダイマーを安定させることで,Gタンパク質とベータアレスティン経路を選択的に活性化します. これは,自閉症や統合失調症における社会的欠陥に対する新しい治療戦略を提供します.

キーワード:
偏ったアゴニズム.Gタンパク質は,G型タンパク質である.ホモバイヴァレンスのリガンド.ホモダイマー (ホモダイマー) とは,ホモダイマー (ホモディマー) とは,ホモダイマー (ホモディマー) とは,ホモダイマー (ホモディマー) とは,ホモディマー (ホモディマー) とは,ホモディマー (ホモディマー) とは,ホモディマー (ホモディマー) とは,ホモディマー (ホモディマー) とは.オキシトシン受容体は,オキシトシン受容体にβ-アレスティンである.

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