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Updated: Feb 20, 2026

Functional Assessment of Intestinal Permeability and Neutrophil Transepithelial Migration in Mice using a Standardized Intestinal Loop Model
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トリプトファンインドール代謝物は,アリル炭化水素受容体駆動型インタールイキン22の生産を通じて,アナストモティック漏れを減少させます

Vasiliki Bantavi1, Laura Gloeck2, Patrick Leven2

  • 1Department of General, Visceral, Thoracic and Vascular Surgery, University Hospital Bonn, University of Bonn, Bonn, Germany; Tytgat Institute for Liver and Intestinal Research, Amsterdam Gastroenterology Endocrinology and Metabolism, Amsterdam University Medical Centers, University of Amsterdam, Amsterdam, The Netherlands.

Cellular and molecular gastroenterology and hepatology
|February 18, 2026
PubMed
まとめ

アリル炭化水素受容体 (AhR) とIL-22をトリプトファン代謝物で刺激することで,結腸直腸がん手術後のアナストモティックリーケージ (AL) を予防することができます. ダイエット介入と合成アゴニストは,治癒の改善とALの合併症の軽減に有望であることが示されています.

キーワード:
アリル炭化水素受容体 アリル炭化水素受容体は,インタールイウキン-22腸内アナストモティック漏れトリプトファンの代謝

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