レゾルヴィンE1とレゾルヴィンE2は,ヒトのマクロファージのようなU937細胞におけるユビキチン-プロテアソーム媒介の分解により,サイクロオキシゲナーゼ-2発現を抑制する

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Updated: Feb 20, 2026

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Ayaka Hamaguchi1, Hayato Fukuda2, Mizuki Watanabe3

  • 1Department of Pharmacology for Life Sciences, Graduate School of Pharmaceutical Sciences & Graduate School of Biomedical Sciences, Tokushima University, Tokushima 770-8505, Japan.

Prostaglandins & other lipid mediators
|February 18, 2026
PubMed
まとめ

レゾルビンEシリーズ (RvEs) は,マクロファージにおける炎症性サイクロオキシゲナーゼ-2 (COX-2) タンパク質発現を減少させます. このメカニズムは,プロスタグランジンE2 (PGE2) の生成を低下させ,副作用が少ない新しい抗炎症薬の可能性を秘めています.

キーワード:
レゾルヴィンEシリーズサイクロオキシゲネーゼ-2マクロファージ (マクロファージ) とは決議案を提出する.ユビキチン-プロテアソーム系システム

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