関連する実験動画

Updated: Feb 20, 2026

High-Throughput Cellular Profiling of Targeted Protein Degradation Compounds Using HiBiT CRISPR Cell Lines
05:33

High-Throughput Cellular Profiling of Targeted Protein Degradation Compounds Using HiBiT CRISPR Cell Lines

Published on: November 9, 2020

11.2K

標的型タンパク質分解のためのブリッジド PROTAC,DNAベースの PROTAC,水害性タグ技術

Pengcheng Gao1, Yue Zhong1, Kaixiu Luo1

  • 1Mount Sinai Center for Therapeutics Discovery, Departments of Pharmacological Science, Oncological Science and Neuroscience, Mount Sinai Tisch Cancer Center, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.

Advanced drug delivery reviews
|February 18, 2026
PubMed
まとめ

タンパク質溶解標的キメラ (PROTACs) は,ユビキチン-プロテアソーム系を通じて標的タンパク質を分解することによって,新しい治療アプローチを提供します. 新しいPROTAC技術は,以前は薬剤で治療できなかったタンパク質をターゲットにすることで,治療可能な疾患の範囲を拡大します.

キーワード:
ブリッジド・プロタックDNAベースのPROTACはハイドロフォビックタグターゲットを絞ったタンパク質の分解

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Author Spotlight: Evaluating Biophysical Assays for Characterizing PROTACS Ternary Complexes07:22

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Chemical Inactivation of the E3 Ubiquitin Ligase Cereblon by Pomalidomide-based Homo-PROTACs10:44

Chemical Inactivation of the E3 Ubiquitin Ligase Cereblon by Pomalidomide-based Homo-PROTACs

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The ubiquitin-proteasome pathway is a well-known mechanism utilized by eukaryotic cells to remove cytoplasmic proteins that are misfolded, damaged, or no longer needed. In this pathway, the protein that needs to be eliminated undergoes a process called ubiquitination, where a chain of ubiquitin molecules is attached to the 48th lysine residue of the target protein. This ubiquitin modification helps the proteasome distinguish between a target protein and a healthy protein.
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