関連する実験動画

Updated: Feb 20, 2026

Monitoring Protein Aggregation Kinetics In Vivo using Automated Inclusion Counting in Caenorhabditis elegans
06:49

Monitoring Protein Aggregation Kinetics In Vivo using Automated Inclusion Counting in Caenorhabditis elegans

Published on: December 17, 2021

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Hsp40のコチャペロンDNAJC7はポリグルタミン濃縮を調節し,ポリグリシン濃縮に対する文脈依存的な効果を示しています

Biswarathan Ramani1, Kean Ehsani1, Martin Kampmann2

  • 1Department of Pathology, University of California, San Francisco, San Francisco, CA, USA.

The Journal of biological chemistry
|February 18, 2026
PubMed
まとめ

研究者らは,ポリグルタミン (polyQ) とポリグリシン (polyG) の疾患におけるタンパク質集積を研究するために新しい細胞モデルを開発した. Hsp40のコチャペロンDNAJC7は,polyQ集積の主要な抑制剤として特定され,polyG集積にも影響を及ぼしています.

キーワード:
アグリゲーション アグリゲーション アグリゲーションチャプロン (Chaperone) とは高通量スクリーニング神経変性神経変性とはポリグルタミン症候群であるポリグルタミン症候群.

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