慢性炎症状態と,成人男性における血清テストステロンおよび自由テストステロンの関連性
Si-Zheng Zhang1, Yu-Hang Meng2, Shuai-Dang Qi1
1Guang'anmen Hospital, China Academy of Chinese Medical Sciences, Beijing, People's Republic of China.
まとめ
SIRIとAISIで測定されるより高い全身性炎症は,男性におけるテストステロンと自由テストステロンの低下と関連しています. これらの関連は,炎症が男性ホルモンレベル,特に全年齢の血清テストステロンに影響を及ぼすことを示唆しています.
科学分野:
- 内分泌学と新陳代謝について
- 免疫学 免疫学とは
- 男性の健康についてです.
背景:
- 慢性炎症は,生化学的ヒポゴナディズムに潜在的に寄与する要因です.
- 複合性炎症指標と低性子症との関連に関する証拠は限られている.
- この研究では,テストステロンレベルに関連した新規の炎症指数を調査しています.
研究 の 目的:
- 成人男性における全身炎症反応指数 (SIRI) と全身炎症総指数 (AISI) と血清テストステロンおよび自由テストステロン (FT) の関連性を調べる.
- 炎症マーカーと生化学的ヒポゴナディズムとの関係を調査する.
主な方法:
- NHANES 2011-2016年と2021-2023年のデータを活用し,テストステロンの男性7,576人,FTの男性3,590人を含む.
- 多変数回帰,滑らかな曲線,値効果分析,年齢層分析を用いた.
- 複合炎症指標としてSIRIとAISIを計算した.
主要な成果:
- SIRIとAISIの上昇は,血清のテストステロンとFTのレベル低下と有意に関連していました (P < 0.0001).
- 最も低いテストステロンのレベルは,SIRIとAISIの最高四分位数で観察されました.
- 非線形逆関連は,両方の指数と血清テストステロンとの間に発見されました; AISIはまた,FTとの非線形関連を示し,SIRIはFTとの線形逆関連を示しました.生化学的ヒポゴナジズムは,血清テストステロンによって定義されたときに,炎症と正に関連していました.
結論:
- SIRIとAISIは,成人男性における血清テストステロンの低下と独立して関連しています.
- 炎症指数と自由テストステロン (FT) の関連性は年齢に依存しています.
- 炎症マーカーは,男性のホルモン健康に関する貴重な洞察を提供します.
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