関連する実験動画

Updated: Feb 20, 2026

G Protein-selective GPCR Conformations Measured Using FRET Sensors in a Live Cell Suspension Fluorometer Assay
09:12

G Protein-selective GPCR Conformations Measured Using FRET Sensors in a Live Cell Suspension Fluorometer Assay

Published on: September 10, 2016

10.1K

適合バイオセンサは,GPCRによる内体Gタンパク質の調節をGPCRによって定義する

Brian Wysolmerski1,2, Nicole M Fisher1, Andrew N Dates1

  • 1Department of Psychiatry and Behavioral Sciences, University of California, San Francisco, San Francisco, CA, USA.

Nature communications
|February 18, 2026
PubMed
まとめ

Gタンパク質結合受容体 (GPCRs) は,持続的なシグナル伝達のためにGαsをエンドソームに移動しますが,活動には内部化が必要です. この研究では,Gsの濃度と活性を制御する明確なプラズマ膜とエンドソームのGPCR-Gタンパク質結合メカニズムが明らかになりました.

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