Jove
Visualize
お問い合わせ
JoVE
x logofacebook logolinkedin logoyoutube logo
JoVEについて
概要リーダーシップブログJoVEヘルプセンター
著者向け
出版プロセス編集委員会範囲と方針査読よくある質問投稿
図書館員向け
推薦の声購読アクセスリソース図書館諮問委員会よくある質問
研究
JoVE JournalMethods CollectionsJoVE Encyclopedia of Experimentsアーカイブ
教育
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab Manual教員リソースセンター教員サイト
利用規約
プライバシーポリシー
ポリシー

関連する概念動画

Cranial and Spinal Meninges01:19

Cranial and Spinal Meninges

4.2K
The cranial and spinal meninges are complex protective structures surrounding the central nervous system (CNS), consisting of the brain and spinal cord. These meninges consist of the dura mater, the arachnoid mater, and the pia mater. They protect the CNS, provide structural support, and aid in circulating cerebrospinal fluid (CSF).
Cranial Meninges
These meningeal layers cover the cranium. The dura mater is the outermost layer of cranial meninges. It is a thick and durable membrane of dense...
4.2K
Cerebrospinal Fluid01:21

Cerebrospinal Fluid

6.5K
Cerebrospinal fluid (CSF) is a colorless liquid that flows around the brain and the spinal cord, playing a vital role in the protection, support, and overall function of the central nervous system (CNS). CSF production, circulation, and absorption are tightly regulated processes essential for the brain and spinal cord to function properly.
CSF Production
CSF is produced mainly in the choroid plexus, a network of capillaries and ependymal cells located within the ventricular system of the brain....
6.5K
Anatomy of the Brain: Ventricles01:18

Anatomy of the Brain: Ventricles

9.4K
There are hollow fluid-filled cavities known as ventricles deep inside the human brain. There are two lateral ventricles, one in each cerebral hemisphere, and each has three different projections — the anterior, inferior, and posterior horns visible from the lateral side. A thin membrane called the septum pellucidum separates the two lateral ventricles. The slender third ventricle in the diencephalon is connected to each lateral ventricle via a channel called the interventricular foramen.
9.4K
Veins of Head and Neck01:19

Veins of Head and Neck

6.0K
The blood drainage from the head and neck is primarily managed by three pairs of veins: the external jugular, internal jugular, and vertebral veins. The external jugular veins drain superficial scalp and face structures, passing over the sternocleidomastoid muscles to empty into the subclavian veins.
On the other hand, the vertebral veins, unlike their arterial counterparts, are not primarily responsible for brain drainage. Instead, they drain the cervical vertebrae, spinal cord, and some small...
6.0K
Cranial Bones: Lateral View01:27

Cranial Bones: Lateral View

7.4K
The lateral view of the cranium is dominated by temporal, sphenoid, and ethmoid bones.
The temporal bone forms the lower lateral side of the skull. The temporal bone is subdivided into several regions. The flattened upper portion is the squamous portion of the temporal bone. Below this area and projecting anteriorly is the zygomatic process of the temporal bone, which forms the posterior portion of the zygomatic arch. Posteriorly is the mastoid portion of the temporal bone. Projecting...
7.4K
The Blood-brain Barrier00:49

The Blood-brain Barrier

53.7K
Overview
53.7K

こちらも読む

関連記事

共著者、ジャーナル、引用グラフによってこの研究に関連する記事。

並び替え
Same author

Why microglial repair programs fade.

Cell research·2026
Same author

Extracellular vesicles from wild-type Epstein-Barr virus-transformed B-cells export host DNA and EBV EBER1.

bioRxiv : the preprint server for biology·2026
Same author

Teaching NeuroImage: Latent Axonal Degeneration in Patient With Anterior Circulation Stroke.

Neurology·2026
Same author

Safety, Tolerability, and Pharmacokinetics of 6-Diazo-5-Oxo-L-Norleucine in Malawian Adults With and Without Malaria: A Phase 1 Dose-Escalation Clinical Trial.

The Journal of infectious diseases·2026
Same author

Gadolinium-Enhanced Portable Ultra-Low-Field MRI for Evaluating Various Intracranial Pathologies.

AJNR. American journal of neuroradiology·2026
Same author

Using Class and Domain Information to Address Domain Shift in Federated Learning.

IEEE transactions on neural networks and learning systems·2026

関連する実験動画

Updated: Feb 20, 2026

Author Spotlight: Investigating the Complex Immune Response Following Brain Ischemia
06:28

Author Spotlight: Investigating the Complex Immune Response Following Brain Ischemia

Published on: July 26, 2024

4.8K

非常にダイナミックなダラルシヌスは,髄膜免疫を支える.

Kelly L Monaghan1, Nagela G Zanluqui1, Yijun Su2

  • 1Viral Immunology and Intravital Imaging Section, National Institute of Neurological Disorders and Stroke (NINDS), National Institutes of Health (NIH), Bethesda, MD, USA.

Nature
|February 18, 2026
PubMed
まとめ

かつては被動的と考えられていたダラル静脈副鼻腔は,ダイナミックな神経免疫界面です. それらはRAMP1/2に依存するメカニズムを通じて,脳防御に不可欠な液体と免疫細胞の流れを調節します.

さらに関連する動画

Isolating Central Nervous System Tissues and Associated Meninges for the Downstream Analysis of Immune cells
09:35

Isolating Central Nervous System Tissues and Associated Meninges for the Downstream Analysis of Immune cells

Published on: May 19, 2020

11.0K
Dural Stimulation and Periorbital von Frey Testing in Mice As a Preclinical Model of Headache
05:40

Dural Stimulation and Periorbital von Frey Testing in Mice As a Preclinical Model of Headache

Published on: July 29, 2021

9.9K

関連する実験動画

Last Updated: Feb 20, 2026

Author Spotlight: Investigating the Complex Immune Response Following Brain Ischemia
06:28

Author Spotlight: Investigating the Complex Immune Response Following Brain Ischemia

Published on: July 26, 2024

4.8K
Isolating Central Nervous System Tissues and Associated Meninges for the Downstream Analysis of Immune cells
09:35

Isolating Central Nervous System Tissues and Associated Meninges for the Downstream Analysis of Immune cells

Published on: May 19, 2020

11.0K
Dural Stimulation and Periorbital von Frey Testing in Mice As a Preclinical Model of Headache
05:40

Dural Stimulation and Periorbital von Frey Testing in Mice As a Preclinical Model of Headache

Published on: July 29, 2021

9.9K

科学分野:

  • 神経免疫学 神経免疫学とは
  • 血管生物学 血管生物学
  • 脳脊髄液のダイナミクス

背景:

  • 中枢神経系の髄膜には,複雑な免疫ネットワークが含まれています.
  • ドゥラル・ヴァーナス・サイヌス (Dural venous sinuses) は,ドゥーラ・マター (dura mater) の一部であり,伝統的に受動的な脳血流として見なされている.
  • これらのシヌスは,重要な神経免疫インターフェースを表しています.

研究 の 目的:

  • デュラルシヌスとその内皮細胞のダイナミックな性質を調査する.
  • このインターフェースで血流,液体の動き,免疫監視を調節するメカニズムを理解する.
  • 内圧の調節と抗ウイルス防御におけるシナスの役割を明らかにする.

主な方法:

  • ネズミの腸内顕微鏡検査
  • RAMP1およびRAMP2に依存するシグナル伝達経路の分析.
  • シヌス内皮細胞 (SEC) の境界ダイナミクスと免疫細胞の密輸の評価.

主要な成果:

  • デュラルシヌスは,RAMP1依存の滑らかな筋肉の活動を通じて,動的収縮/伸縮を示す.
  • 上部サギタルシヌスにある特殊な,フェネストラ付きのSECは,液体と微生物の交換を容易にする.
  • SECはRAMP2に依存した方法で細胞間境界を動的に制御し,免疫細胞の密輸を制御します.
  • SECダイナミクスの障害は,抗ウイルス免疫を低下させ,病原体の侵入を促進します.

結論:

  • デュラルシヌスは,積極的,ダイナミックな静脈構造であり,受動的導管ではありません.
  • RAMP2によって調節されるシヌス内皮細胞動態は,免疫監視と脳保護に不可欠です.
  • これらの発見は,神経炎症と宿主の防御を調節する際に,持続性シヌスの新たな役割を明らかにしています.