関連する実験動画

Updated: Feb 20, 2026

Dual-Dye Optical Mapping of Hearts from RyR2R2474S Knock-In Mice of Catecholaminergic Polymorphic Ventricular Tachycardia
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Dual-Dye Optical Mapping of Hearts from RyR2R2474S Knock-In Mice of Catecholaminergic Polymorphic Ventricular Tachycardia

Published on: December 22, 2023

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RYKは,MASHを駆動するGPNMB受容体です

Yue Xi1,2, Waner Zeng1,2, Jie Luo1,2

  • 1State Key Laboratory of Metabolism and Regulation in Complex Organisms, College of Life Sciences, Wuhan University, Wuhan, China.

Nature
|February 18, 2026
PubMed
まとめ

メタボリック機能障害関連ステアトヘパтитиス (MASH) の進行は,グリコプロテイン非転移性メラノーマタンパク質B (GPNMB) エクトドメイン (G-ECD) がレセプターチロシンキナーゼ (RYK) に結合することによって引き起こされます. このGPNMB-RYK軸をターゲットにすることで,MASHの有望な治療戦略が提供されます.

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