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Updated: Feb 20, 2026

Isolation Protocol of Mouse Monocyte-derived Dendritic Cells and Their Subsequent In Vitro Activation with Tumor Immune Complexes
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統合されたストレス反応は,リポカリン2を通じて免疫逃避を促進します

Jozef P Bossowski1, Ray Pillai1,2,3, John Kilian4,5

  • 1Department of Pathology, New York University Grossman School of Medicine, New York, NY, USA.

Nature
|February 18, 2026
PubMed
まとめ

癌細胞は統合ストレス反応 (ISR) と活性化転写因子4 (ATF4) を使用して,治療に抵抗します. ATF4-リポカリン2 (LCN2) 軸をターゲットにすることで,腫瘍に対するT細胞免疫力を高めます.

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