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Updated: Feb 20, 2026

A Robust Discovery Platform for the Identification of Novel Mediators of Melanoma Metastasis
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統合的マルチオミクスは,メラノーマの薬物反応ネットワークとARID1A依存の耐性メカニズムを定義します

Charlie George Barker1,2, Sumana Sharma1,3, Ana Mafalda Santos3

  • 1European Molecular Biology Laboratory, European Bioinformatics Institute (EMBL-EBI), Wellcome Genome Campus, Hinxton, Cambridgeshire, CB10 1SD, UK.

Molecular systems biology
|February 18, 2026
PubMed
まとめ

メラノーマにおけるARID1A喪失は,細胞シグナル伝達と免疫回避経路を変更することによって,BRAF/MAPK阻害剤に対する耐性を促進する. PRKD1,JUN,NCK1をターゲットにすることで,この抵抗を克服することができます.

キーワード:
アリド1A アリド1Aデータインテグレーション データインテグレーション薬剤耐性 薬剤耐性 薬剤耐性 薬剤耐性 薬剤耐性 薬剤耐性 薬剤耐性メラノーマはメラノーマです.ネットワーク分析 ネットワーク分析

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