性別に依存した行動,脳構造,機能的接続性,および思春期間に псилоцибин に曝露した後の感覚知覚の発達変化
Itishree Sahoo1, Sairam Masadi1, Ashwath Maheswari1
1Center for Translational NeuroImaging, Northeastern Univ, Boston, MA, USA.
まとめ
十代のサイロシビン曝露は,脳の発達を変化させ,感情的行動と神経解剖学,特に男性に影響します. この早期の曝露は,神経可塑性や脳の接続性に対して長期的な影響を及ぼします.
科学分野:
- 神経科学は神経科学である.
- 発達生物学 発達生物学について
- 精神薬理学 (Psychopharmacology) とは,精神薬理学 (Psychopharmacology) とは,精神薬理学 (Psychopharmacology) とは,精神薬理学 (Psychopharmacology) とは,精神薬理学 (Psychopharmacology) とは,精神薬理学 (Psychopharmacology) とは,精神薬理学 (Psychopharmacology) とは,精神薬理学 (Psychopharmacology) とは,精神薬理学 (Psychopharmacology) とは,精神薬理学 (Psychopharmacology) とは,精神薬理学 (Psychopharmacology) とは,精神薬理学 (Psychopharmacology) とは,精神薬理学 (Psychopharmacology) とは,精神薬理学 (Psychopharmacology) とは,精神薬理学 (Psychopharmacology) とは
背景:
- 幻覚剤のサイロサイビンは,神経生物学的および行動的変化を誘発する.
- 青春期は,特に前頭脳において,脳神経可塑性が高まる重要な時期です.
- 早期の曝露は,脳の発達と機能に長期的な影響を及ぼします.
研究 の 目的:
- マウスの感情的行動,神経解剖学,神経回路,および表遺伝学に対する青少年サイロシビン曝露の長期的な影響を調査する.
- 敏感な発達ウィンドウ中のサイロシビン曝露が成人期にわたって脳の構造と機能に影響を及ぼすかどうかを判断する.
主な方法:
- 十代の雄性・雌性マウスは,経口でサイロサイビンまたはベイクターを投与された.
- 青春期後,マウスはMRI (ヴォクセルベースの形態測定,拡散加重画像,静止状態のfMRI) と行動検査を受けた.
- 前頭前野の皮質組織は,先天性および神経可塑性タンパク質マーカーを分析した.
主要な成果:
- サイロシビンに曝された女性では,露天での移動能力が低下し,両方の性別は,報酬/嫌悪刺激に対する感受性が低下した.
- 地域的な脳容量の減少と水分拡散性の変化は,男性においてより顕著であった.
- 特に前頭前皮質を含む,グローバルおよび地域機能的接続性の増加は,両方の性別で観察されました.
- 男性は,先頭前野皮質におけるエピジェネティックおよび神経可塑性タンパク質マーカーのレベルが低下したことを示した.
結論:
- 青少年のサイロシビン曝露は,長期的な神経発達に重大な影響を及ぼします.
- 観察された変化には,脳の構造の変化,機能的な接続性の向上,刺激に対する認識の変化が含まれる.
- 男性は,これらの長期的な影響に対してより脆弱であるようで,前頭前皮質におけるより大きな構造的変化と減少したタンパク質マーカーによって証明されています.
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