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Electrospray Ionization (ESI) Mass Spectrometry01:12

Electrospray Ionization (ESI) Mass Spectrometry

2.5K
Higher molecular weight biomolecules are nonvolatile compounds that may decompose before ionizing or vaporizing during mass analysis with conventional electron impact ionization methods. Accordingly, electrospray ionization (ESI) is the favored method for vaporizing and ionizing biomolecules as it circumvents rapid fragmentation and enables the recording of mass signals for the entire biomolecule.
ESI utilizes electrical energy to transfer ions from the liquid phase of the sample into the...
2.5K
Mass Analyzers: Common Types01:19

Mass Analyzers: Common Types

1.6K
The quadrupole mass analyzer consists of four cylindrical metal rods arranged in a diamond carrying a DC voltage and a radio-frequency AC voltage. The motion of ions through the quadrupole depends on the field strength, causing only ions of a certain m/z to resonate successfully and strike the detector at a given field strength. Though the transmission rate for these analyzers is high, the exact elemental composition of the sample is not determined because of low resolution; however, they are...
1.6K
Electrogravimetric Analysis: Overview01:30

Electrogravimetric Analysis: Overview

834
Electrogravimetric analysis measures the weight of an analyte deposited electrolytically onto a suitable working electrode. This method involves applying a potential to a pre-weighed electrode submerged in a solution, which results in the desired substance being deposited through reduction at the cathode or oxidation at the anode. The electrode's weight is recorded after deposition, and the difference in weight gives the analyte's weight in the solution.
To test the completeness of the...
834
Mass Analyzers: Overview01:13

Mass Analyzers: Overview

1.8K
The mass analyzer is a crucial component of the mass spectrometer. In the ionization chamber, the vaporized sample is bombarded with a high-energy electron beam to generate a radical cation and further fragment into neutral molecules, radicals, and cations. A series of negatively charged accelerator plates accelerate the cations into the mass analyzer. The mass analyzer separates ions according to their mass-to-charge (m/z) ratios and then directs them to the detector. The common types of mass...
1.8K
Capillary Electrophoresis: Applications01:30

Capillary Electrophoresis: Applications

1.5K
Capillary electrophoretic separations offer various modes, each with unique applications. These modes include capillary zone electrophoresis, capillary gel electrophoresis, capillary array electrophoresis, capillary isoelectric focusing, capillary isotachophoresis, micellar electrokinetic chromatography, and capillary electrochromatography.
Capillary zone electrophoresis (CZE) separates ionic components based on their electrophoretic mobility. It has been used to separate proteins, amino acids,...
1.5K
Mass Spectrometers01:16

Mass Spectrometers

9.2K
This lesson details the instrumentation of a mass spectrometer—a physical instrument to perform mass spectrometry on analyte molecules and record the characteristic mass spectra. This is achieved via three chief functions:
9.2K

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Updated: Feb 20, 2026

Cell-Lineage Guided Mass Spectrometry Proteomics in the Developing Frog Embryo
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Cell-Lineage Guided Mass Spectrometry Proteomics in the Developing Frog Embryo

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セグメンテッド電極軌道軌道のフィールド最適化

Yuze Zhao1, Bingsheng Tu1

  • 1The Key Laboratory of Nuclear Physics and Ion Beam Applications of the Ministry of Education, Department of Nuclear Science and Technology, the Institute of Modern Physics, Fudan University, Shanghai 200433, China.

Journal of the American Society for Mass Spectrometry
|February 18, 2026
PubMed
まとめ
この要約は機械生成です。

この研究は,超高質量解像度のためのセグメンテッド電極オービトラップの不完全なポテンシャルフィールドを最適化します. 電極の電圧を調整することで,製造上の不完全性を補い,20万以上の質量解像度を達成します.

キーワード:
周波数シフトは周波数のシフトです.不完全なフィールドは不完全なフィールドです.質量解像度の高い質量解像度を持つ数値シミュレーションによる数値シミュレーションオービトラピング (orbitrap)

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High-throughput and Comprehensive Drug Surveillance Using Multisegment Injection-Capillary Electrophoresis-Mass Spectrometry
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Sample Preparation for Mass-spectrometry-based Proteomics Analysis of Ocular Microvessels
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Sample Preparation for Mass-spectrometry-based Proteomics Analysis of Ocular Microvessels

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Last Updated: Feb 20, 2026

Cell-Lineage Guided Mass Spectrometry Proteomics in the Developing Frog Embryo
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Cell-Lineage Guided Mass Spectrometry Proteomics in the Developing Frog Embryo

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High-throughput and Comprehensive Drug Surveillance Using Multisegment Injection-Capillary Electrophoresis-Mass Spectrometry
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Sample Preparation for Mass-spectrometry-based Proteomics Analysis of Ocular Microvessels
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Sample Preparation for Mass-spectrometry-based Proteomics Analysis of Ocular Microvessels

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科学分野:

  • アナリティカル・ケミストリー (Analytical Chemistry) とは
  • 物理化学 物理化学
  • インストゥルメンタル分析

背景:

  • 従来型のスピンドル形オービトラップは,製造に課題をもたらします.
  • セグメンテッド電極オービトラップは,より製造可能な設計を提供します.
  • オービトラップの不完全なポテンシャルフィールドは,質量解像度を制限します.

研究 の 目的:

  • セグメンテッド電極 Orbitrap.p.の不完全なポテンシャルフィールドの最適化方法を提示する.
  • イオン軌道と質量解像度に対する潜在的なフィールド不完全性の影響を分析する.
  • フィールド最適化による超高質量解像度の達成を実証する.

主な方法:

  • 有限要素法を用いた数値シミュレーション.
  • イオン軌道と周波数シフトの分析.
  • ハーモニックフィールドの誤差をキャンセルするために電極電位の最適化.

主要な成果:

  • 質量の解像度は20万を超えました.
  • 高度のハーモニックポテンシャルによって引き起こされる周波数シフトの有効なキャンセルが実証されています.
  • バイアス電圧の調整は,許容範囲内の機械的エラーを補償できることを示しました.

結論:

  • 提案された最適化方法は,セグメンテッド電極オービトラップの不完全なハーモニックポテンシャルフィールドを効果的に処理します.
  • この最適化された設計により,超高質量解像度を実現できます.
  • この方法は,製造の許容値にもかかわらず,信頼性の高い質量解像度を保証します.