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Updated: Feb 20, 2026

Anionic Polymerization of an Amphiphilic Copolymer for Preparation of Block Copolymer Micelles Stabilized by π-π Stacking Interactions
10:53

Anionic Polymerization of an Amphiphilic Copolymer for Preparation of Block Copolymer Micelles Stabilized by π-π Stacking Interactions

Published on: October 10, 2016

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PBPKを使用して,長期作用の注射剤の標的生物予測溶解プロフィールをシミュレートする - 重要な生物利用可能性属性については,どこから始めるべきですか?

Hannah Cleary1,2, Nikoletta Fotaki3, Tim Persoons2,4

  • 1EPSRC-Research Ireland Centre for Doctoral Training in Transformative Pharmaceutical Technologies, School of Pharmacy and Pharmaceutical Sciences, Trinity College Dublin, Dublin, Ireland.

CPT: pharmacometrics & systems pharmacology
|February 19, 2026
PubMed
まとめ

長期作用注射剤 (LAI) の生物予測溶解試験の開発には,in vivoパラメータの理解が必要です. 生理学的にベースされた薬動力学 (PBPK) モデルは,より遅いLAI溶解をシミュレートし,in vitro試験の開発をガイドしました.

キーワード:
生物学的利用可能性の属性は,バイオ予測性パフォーマンステスト溶解テスト 溶解テスト長時間作用する注射剤です.ファルマコキネティックモデリング

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