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Updated: Feb 20, 2026

Rapid in vivo Drug Response Prediction Using Leukemia Cell Grafts in Zebrafish Embryos
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フィジオロジカル・ベース・ファルマコキネティクス・バーチャル・ツイン・アプローチ フルダラビン投与のための小児血液形成幹細胞移植におけるフルダラビン投与

Mourad Mseddi1, Christa Nath2,3,4, Khalil Ben Hassine1,5

  • 1CANSEARCH Research Platform for Pediatric Oncology and Hematology, Department of Pediatrics, Gynecology, and Obstetrics, University of Geneva, Geneva, Switzerland.

CPT: pharmacometrics & systems pharmacology
|February 19, 2026
PubMed
まとめ

この研究では,血造性幹細胞移植 (HSCT) を受けている小児患者のフルダラビン (インフルエンザ) 薬物曝露を正確に予測するために,生理学的にベースの薬剤動力学 (PBPK) モデルを開発しました. このモデルは,改善された治療結果のためのパーソナライズされた投与を可能にします.

キーワード:
化学療法 化学療法とはフルダラビン (Fludarabine) とは造血幹細胞移植 造血幹細胞移植小児科の小児科生理学的に基礎づけられた薬理動力学.バーチャルツイン 仮想ツイン

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