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Updated: Feb 20, 2026

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髪のエチルグルキュロニド: 10年間の概要
Sara Casati1,2, Alessandro Ravelli1, Roberta F Bergamaschi1
1Laboratorio di Tossicologia Forense, Dipartimento di Scienze Biomediche, Chirurgiche ed Odontoiatriche, Università Degli Studi di Milano, Milan, Italy.
Drug testing and analysis
|February 19, 2026
まとめ
この研究では,長期のアルコール消費傾向を評価するために68,000以上のサンプルでヘアエチルグルキュロニド (EtG) を分析しました. 結果は,EtGレベルが人口統計と季節によって異なることを示しており,髪のEtG検査を確認しています.
科学分野:
- 法医学毒理学 法医学毒理学
- アナリティカル・ケミストリー (Analytical Chemistry) とは
- 依存症医学 薬物中毒医学
背景:
- ヘアエチルグルキュロニド (EtG) 分析は,長期的なアルコール消費量を評価するための信頼できる方法を提供します.
- EtGの分布パターンを理解することは,禁欲と消費レベルを解釈する上で極めて重要です.
- 以前の研究はEtGを調査したが,多様な集団からの10年分の大規模なデータが欠けていた.
研究 の 目的:
- 髪のEtG分析を用いて,10年間の長期アルコールの消費パターンを評価する.
- 人口統計的要因 (年齢,性別),季節性,およびCOVID-19の流行がEtGレベルに及ぼす影響を調査する.
- 確立されたカットオフを使用して,髪のEtGテストの信頼性と比較性を評価する.
主な方法:
- 北イタリアのコホートから2013年から2022年の間に収集された68,221個の髪のサンプルを遡及的に分析した.
- 高性能液体染色体-質量スペクトロメトリー/質量スペクトロメトリー (HPLC-MS/MS) を使用して髪のEtGの定量化.
- Society of Hair Testing (SoHT) のカットオフ基準に基づくEtGレベルの分類は,禁酒,繰り返し,および慢性的な過度のアルコール摂取によるものです.
主要な成果:
- 試料の13.6%がアルコールの繰り返し摂取 (5
- EtGレベルは,性別,年齢,髪のタイプ (頭,胸,頭,頭),髪のセグメントの長さ,季節 (寒い月はより高い) に基づいて有意な変動を示しました.
- 短期的なCOVID-19の影響は観察されなかったが,アルコールの消費に対するパンデミックの長期的な影響は,髪のEtGを通じて検出された.
結論:
- ヘアEtG検査は,濃度の固有の変動にもかかわらず,長期のアルコール消費を監視するための信頼できる方法です.
- COVID-19 パンデミックのような人口統計的要因,季節性,長期的な社会イベントは,アルコール消費パターンに大きく影響します.
- この研究は,大規模で監視された集団におけるアルコール消費傾向に関する貴重な洞察を提供し,臨床的および法医学的な解釈を支援しています.
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